Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New quality control revealed in immune T cell development

21.11.2016

The research into T cell development within an organ called the thymus revealed for the first time that a protein complex called LUBAC enables 'quality control' of the cells before they are released into the bloodstream.

T cells are an important component of the immune system, orchestrating immune responses in reaction to infections. The thymus is like a 'school' for T cells, training them how to fight infections and eliminating the 'naughty' cells that have the potential to launch dangerous autoimmune attacks on the body's own tissues. Only a small proportion of the T cells that begin their development 'graduate' and are allowed out of the thymus, into the bloodstream - the rest do not survive.


Microscopic view of cells in the thymus, an organ located just above the heart that trains immune T cells to defend the body against viruses and bacteria.

Credit: Walter and Eliza Hall Institute, Australia

Dr Charis Teh, Dr Daniel Gray and colleagues made the discovery, published in the journal Nature Communications, when investigating the link between faulty LUBAC and T cell defects.

Dr Teh said the team were surprised to discover that LUBAC was important for a very late stage of T cell development within the thymus.

"Since the function of the thymus was discovered by Professor Jacques Miller almost 60 years ago, there has been an intense research effort to reveal the intricate details of how immune T cells develop," she said.

"By showing that LUBAC is essential for T cell development, we also revealed a new stage of 'T cell education' that had not previously been appreciated. We're excited by the prospect that this new checkpoint may be important for ensuring autoimmune T cells are not allowed to complete their development," she said.

"In most people, this prevents the development of autoimmune diseases such as type 1 diabetes and multiple sclerosis," Dr Teh said.

Dr Gray said the team hoped that by understanding the newly discovered process better, they may be able to develop new approaches to 'switch off' autoimmune T cells. "This may have therapeutic applications in the future for treating autoimmune diseases," Dr Gray said.

"Another interesting aspect of this research relates to rare inherited immune disorders caused by defects in the genes that encode the components of LUBAC. Our research has provided new insights into how these disorders are linked to faulty T cell function. This may inspire to new immune-based therapies for these conditions," he said.

###

The research was supported by Diabetes Australia, the National Health and Medical Research Council, Cancer Australia, the Australian Research Council, the Leukemia and Lymphoma Society (US), the Wellcome Trust (UK), and the Victorian Government Operational Infrastructure Scheme.

Media Contact

Vanessa S Solomon
communications@wehi.edu.au
61-475-751-811

 @WEHI_research

http://www.wehi.edu.au/ 

Vanessa S Solomon | EurekAlert!

More articles from Life Sciences:

nachricht Enduring cold temperatures alters fat cell epigenetics
19.04.2018 | University of Tokyo

nachricht Full of hot air and proud of it
18.04.2018 | University of Pittsburgh

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

Im Focus: The Future of Ultrafast Solid-State Physics

In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.

Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Diamond-like carbon is formed differently to what was believed -- machine learning enables development of new model

19.04.2018 | Materials Sciences

Electromagnetic wizardry: Wireless power transfer enhanced by backward signal

19.04.2018 | Physics and Astronomy

Ultrafast electron oscillation and dephasing monitored by attosecond light source

19.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>