Scientists at the Leibniz-Institute of Plant Biochemistry (IPB) in Halle/Saale (Germany) have fully elucidated the biosynthesis of carnosic acid. This discovery allowed the plant researchers around Prof. Alain Tissier to produce the economically valuable plant material by biotechnological means in yeast cells. The project was published in the renowned journal Nature Communications.
Carnosic acid is a natural antioxidant that is found in the leaves of rosemary and sage. It is used worldwide as a preservative and flavor in meat products, oils, fats, sauces and animal feed. Carnosic acid, for which the demand is steadily increasing, is still extracted from rosemary plants, which grow slowly.
Carnosic acid is still obtained from rosemary. However, biotechnological production processes could be developed soon.
Dried leaves of sage or rosemary contain at most 2.5 percent of carnosic acid, necessitating a large amount of plant material to ensure the production of the antioxidant on industrial scale. Furthermore, the complex structure of carnosic acid makes an industrial synthetic process unrealistic.
The biosynthesis of carnosic acid within the plant takes place in several reaction steps, which are catalyzed by different enzymes. The enzyme that catalyzes the last step of the reaction chain had not yet been discovered. This knowledge-gap has now been closed by the IPB researchers.
They discovered an additional, previously unknown intermediate and also new enzymes, which were described and characterized by them. With the knowledge of all involved reaction partners, the scientists were able to introduce the genes coding for the corresponding enzymes into yeast cells and make them produce carnosic acid. This is the first step in the development of a biotechnological production process for the antioxidant.
Carnosic acid is also the starting material for the biosynthesis of many other phenolic diterpenes, which act as bioactive substances against inflammation, cancer and various neurodegenerative diseases.
Also for this reason, it will be interesting to produce carnosic acid in the future with biotechnology-based processes and thus independently of climate fluctuations, soil quality and harvest yields.
Ulschan Scheler, Wolfgang Brandt, Andrea Porzel, Kathleen Rothe, David Manzano, Dragana Bozic, Dimitra Papaefthimiou, Gerd Ulrich Balcke, Anja Henning, Swanhild Lohse, Sylvestre Marillonnet, Angelos K. Kanellis, Albert Ferrer & Alain Tissier. Elucidationof the bioynthesis of carnosic acid and its reconstitution in yeast. Nature Communications 7: 12942, doi:10.1038/ncomms12
Prof. Alain Tissier
Leibniz Institute of Plant Biochemistry
Tel.: +49 345 5582 1500
Dipl.Biol. Sylvia Pieplow | idw - Informationsdienst Wissenschaft
Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg
Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
18.01.2018 | Life Sciences
18.01.2018 | Life Sciences
18.01.2018 | Earth Sciences