Scientists at the Leibniz-Institute of Plant Biochemistry (IPB) in Halle/Saale (Germany) have fully elucidated the biosynthesis of carnosic acid. This discovery allowed the plant researchers around Prof. Alain Tissier to produce the economically valuable plant material by biotechnological means in yeast cells. The project was published in the renowned journal Nature Communications.
Carnosic acid is a natural antioxidant that is found in the leaves of rosemary and sage. It is used worldwide as a preservative and flavor in meat products, oils, fats, sauces and animal feed. Carnosic acid, for which the demand is steadily increasing, is still extracted from rosemary plants, which grow slowly.
Carnosic acid is still obtained from rosemary. However, biotechnological production processes could be developed soon.
Dried leaves of sage or rosemary contain at most 2.5 percent of carnosic acid, necessitating a large amount of plant material to ensure the production of the antioxidant on industrial scale. Furthermore, the complex structure of carnosic acid makes an industrial synthetic process unrealistic.
The biosynthesis of carnosic acid within the plant takes place in several reaction steps, which are catalyzed by different enzymes. The enzyme that catalyzes the last step of the reaction chain had not yet been discovered. This knowledge-gap has now been closed by the IPB researchers.
They discovered an additional, previously unknown intermediate and also new enzymes, which were described and characterized by them. With the knowledge of all involved reaction partners, the scientists were able to introduce the genes coding for the corresponding enzymes into yeast cells and make them produce carnosic acid. This is the first step in the development of a biotechnological production process for the antioxidant.
Carnosic acid is also the starting material for the biosynthesis of many other phenolic diterpenes, which act as bioactive substances against inflammation, cancer and various neurodegenerative diseases.
Also for this reason, it will be interesting to produce carnosic acid in the future with biotechnology-based processes and thus independently of climate fluctuations, soil quality and harvest yields.
Ulschan Scheler, Wolfgang Brandt, Andrea Porzel, Kathleen Rothe, David Manzano, Dragana Bozic, Dimitra Papaefthimiou, Gerd Ulrich Balcke, Anja Henning, Swanhild Lohse, Sylvestre Marillonnet, Angelos K. Kanellis, Albert Ferrer & Alain Tissier. Elucidationof the bioynthesis of carnosic acid and its reconstitution in yeast. Nature Communications 7: 12942, doi:10.1038/ncomms12
Prof. Alain Tissier
Leibniz Institute of Plant Biochemistry
Tel.: +49 345 5582 1500
Dipl.Biol. Sylvia Pieplow | idw - Informationsdienst Wissenschaft
Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care
Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
17.11.2017 | Physics and Astronomy
17.11.2017 | Health and Medicine
17.11.2017 | Studies and Analyses