Mosquitoes and malaria: Scientists pinpoint how biting cousins have grown apart

Of about 450 different species of mosquitoes in the Anopheles genus, only about 60 can transmit the Plasmodium malaria parasite that is harmful to people. The team chose 16 mosquito species that are currently found in Africa, Asia, Europe, and Latin America, but evolved from the same ancestor approximately 100 million years ago.

Today, the 16 species have varying capabilities for transmitting malaria and adapting to new environments. The team sequenced their genomes to better understand the evolutionary science behind the differences.

The results, published in today's (Nov. 27, 2014) issue of Science, may advance understanding about the biological differences between mosquitoes that transmit malaria, and ultimately, how species might be more precisely controlled to stop transmission.

“With the availability of genome sequences from Anopheles mosquitoes of divergent lineages, variable adaptations, and differing disease-transmission abilities, we now have the exciting opportunity to significantly improve our understanding of these important malaria vectors and develop new strategies to combat malaria and other mosquito-borne diseases,” said Zhijian Tu, a professor of biochemistry in the College of Agriculture and Life Sciences, and a Fralin Life Science Institute affiliate.

The research was led by Daniel Neafsey, a scientist with the Broad Institute; Robert Waterhouse, a Marie Curie International Outgoing Fellow at the Massachusetts Institute of Technology; and Nora Besansky, a professor from the University of Notre Dame.

In a second related paper, also published today in Science, a key finding was that the most dangerous species, Anopheles gambiae, is able to increase its transmission capabilities by swapping genes at the chromosome level.

“We found out that multiple rearrangements on the sex chromosome prevent the species from completely intermixing, while traits enhancing malaria transmission capabilities can cross species boundaries if other chromosomes encode them,” said Igor Sharakhov, an associate professor of entomology in the College of Agriculture and Life Sciences and a Fralin Life Science Institute affiliate.

The results advance the idea that a genetic process called introgression, where genes from one species flow into another, plays a role in evolution, in this case by enhancing the capacity of mosquitoes to transmit the malaria parasite.

The research in the second paper was led by Matthew Hahn, a professor of biology and informatics at Indiana University, and Besansky.

Other Virginia Tech co-authors involved in the research include Brantley Hall of Christiansburg, Va., a doctoral student in the Genetics, Bioinformatics, and Computational Biology program; Xiaofang Jiang of Wuhan City, China, a doctoral student in the Genetics, Bioinformatics, and Computational Biology program; Anastasia Naumenko of Kurgan, Russia, a doctoral student in entomology in the College of Agriculture and Life Sciences; Ashley Peery of Christiansburg, Va., a doctoral student in entomology in the College of Agriculture and Life Sciences; Chunhong Mao, a senior project associate at the Virginia Bioinformatics Institute, and Maria Sharakhova, a research scientist in entomology in the College of Agriculture and Life Sciences and a Fralin Life Science Institute affiliate.

Media Contact

Lindsay Taylor Key EurekAlert!

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

New yttrium-hydrogen compounds discovered

Researchers at the University of Bayreuth have made a significant scientific breakthrough by discovering new yttrium-hydrogen compounds having serious implications for the research on high-pressure superconductivity. High-pressure superconductivity refers to…

New AI model detects ninety percent of lymphatic cancer cases

Medical image analysis using AI has developed rapidly in recent years. Now, one of the largest studies to date has been carried out using AI-assisted image analysis of lymphoma, cancer…

UTA preps giant particle detectors for neutrino project

Excavation of caverns part of Fermilab’s Deep Underground Neutrino Experiment. With excavation work complete at the site where four gigantic particle detectors for the international Deep Underground Neutrino Experiment (DUNE) will be…

Partners & Sponsors