Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Modular virus-like particles as vaccine platform?

05.06.2018

Virus-like particles (VLP) have been used as effective vaccines for quite a while. The modular combination of antigen and adjuvant in VLPs can further enhance the effect of the vaccine, thus conveying better protection. This was shown based on results obtained by a research group at the Paul-Ehrlich-Institut.
Molecular Immunology reports on these research results online ahead of print on May 28

So-called modular vaccines in which the antigen – the pathogen component against which the immune protection is to be developed – is physically connected (conjugated) to the adjuvant (effect enhancer) convey a significantly stronger immune response than vaccines in which the components are present separately. Modular vaccines are thus particularly immunogenic. The reason for this improved effect is probably the simultaneous transport of both components to the antigen presenting cells.


The combination of antigen+adjuvant in virus-like particles trigger enhanced immune responses as compared to separate delivery of these components. This can be used for the development of new vaccines

Source: PEI

Can the effectiveness of those vaccines which are based on virus-like particles (VLPs) also be enhanced by such a modular construction? A research group of Dr. Zoe Waibler, head of Section 'Product Testing of Immunological Biomedicines' of Division Immunology at the Paul-Ehrlich-Institut (PEI) has investigated this question jointly with researchers of the research group 'Molecular Allergology' and Section 'Product Testing of Immunological Biomedicines', also at the PEI.

Vaccines based on virus particles are of interest because the immune system responds directly to virus particles as part of the normal defence against infections. VLPs already present the basis for vaccines authorised in Europe for the protection against human papilloma viruses.

VLPs do not contain any nucleic acids and cannot replicate in the target cells. Certain VLPs are also an attractive platform for vaccine development because new vaccines can be created from them by interchanging the antigen. Besides, the antigen and the adjuvant can be presented to the immune system on their surface simultaneously.

The researchers of the PEI used chicken egg white (ovalbumin) as model antigen and GM-CSF (granulocyte macrophage-colony stimulating factor) as adjuvant. The receptor for this cytokine can be found on various immune cells which present the antigen to additional immune cells, thus triggering an immune response.

The researchers used various approaches to prove that these modular VLPs activate important immune cells (T-helper cells and cytotoxic T cells). And this stimulation turned out to be significantly stronger if both adjuvant and antigen were presented jointly on these VLPs.

In the next steps, the PEI researchers will check the effects observed in the cell cultures in an animal model and will examine whether protection from defined pathogens can be conveyed using the VLPs thus obtained.

Original Publication
DOI: https://doi.org/10.1016/j.molimm.2018.05.017

Gogesch P, Schülke S, Scheurer S, Mühlebach MD, Waibler Z (2018):
Modular MLV-VLPs co-displaying ovalbumin peptides and GM-CSF effectively induce expansion of CD11b+ APC and antigen-specific T cell responses in vitro.
Mol Immunol Maqy 28 [Epub ahead of print]

The Paul-Ehrlich-Institut, the Federal Institute for Vaccines and Biomedicines, in Langen near Frankfurt/Main is a senior federal authority reporting to the Federal Ministry of Health (Bundesministerium für Gesundheit, BMG). It is responsible for the research, assessment, and marketing authorisation of biomedicines for human use and immunological veterinary medicinal products. Its remit also includes the authorisation of clinical trials and pharmacovigilance, i.e. recording and evaluation of potential adverse effects.

Other duties of the institute include official batch control, scientific advice and inspections. In-house experimental research in the field of biomedicines and life science form an indispensable basis for the manifold tasks performed at the institute.

The Paul-Ehrlich-Institut, with its roughly 800 members of staff, also has advisory functions nationally (federal government, federal states (Länder)), and internationally (World Health Organisation, European Medicines Agency, European Commission, Council of Europe etc.).

Weitere Informationen:

https://www.sciencedirect.com/science/article/pii/S0161589018301640 - Fulltext with link to the pdf-Version (available until July 17)
https://www.ncbi.nlm.nih.gov/pubmed/29852456 - Publication Abstract
https://www.pei.de/EN/information/journalists-press/press-releases/2018/09-modul... - This press release on the Paul-Ehrlich-Institut Website

Dr. Susanne Stöcker |

More articles from Life Sciences:

nachricht Tag it EASI – a new method for accurate protein analysis
20.06.2018 | Max-Planck-Institut für Biochemie

nachricht How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>