Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Metabolomics in Brain Research: What hundreds of biomolecules tell us about our nerve cells

18.05.2015

Researchers at the Luxembourg Centre for Systems Biomedicine (LCSB), of the University of Luxembourg, have, under Dr. Manuel Buttini, successfully measured metabolic profiles, or the metabolomes, of different brain regions, and their findings could help better understand neurodegenerative diseases. The metabolome represents all or at least a large part of the metabolites in a given tissue, and thus, it gives a snapshot of its physiology.

„Our results, obtained in the mouse, are promising“, says Manuel Buttini: “They open up new opportunities to better understand neurodegenerative diseases, such as Parkinson’s, and could offer new ways to intervene therapeutically. In addition, with the help of metabolic profiles, such as those we have measured, the efficacy of novel therapeutic interventions could be tested more efficiently than with more common approaches.“

The researchers have just published their results in the „American Journal of Pathology“ (Am J Pathol 2015, 185: 1-14; http://dx.doi.org/10.1016/j.ajpath.2015.02.016).

Neurodegenerative processes, such as those occurring in Parkinson’s disease, are characterized by pathological alterations of the brain cells: these cells lose their structure and function, a process that is accompanied by changes in their metabolism. Until now, most scientists have always focused on just one or a few aspects of the disease to better describe and understand the underlying mechanisms.

By analysing the whole metabolome however, LCSB researchers have realized a more global approach: they now can analyse hundreds of biomolecules, produced by nerve cells in upper, middle, and lower brain regions of the mouse. In the process, they not only look at healthy brains, but also at brains in which neurodegeneration occurs.

“To study the metabolite signatures of the brain, we used gas-chromatography coupled to mass spectrometry. This approach is particularly suitable for the analysis of samples from complex tissues“, explains Dr. Christian Jäger, one of the three main authors of the study. With metabolic studies, an area in which the LCSB is one of the worldwide leading institutions, one can assess known and still unknown biomolecules in tissue samples.

After the measurements, LCSB-researchers have used a bioinformatical approach known as Machine Learning to specifically derive the metabolic profile of each brain region. These efforts were spearheaded by Dr. Enrico Glaab, the second main author of the study. “We found that a multitude of different molecules together reflect a specific functional state of nerve cells in each brain region.“ By comparing their observations with microscopic analysis of pathologic processes in nerve cells, the LCSB researchers could show which particular metabolic profile is associated with the degeneration of these cells.

“It was clearly the joined efforts of experts from quite different fields, an interdisciplinary approach that is encouraged at LCSB, that made this study possible. In this case, experts in Neurobiology, Biochemistry, Molecular Biology, and Bioinformatics came together to enable the successful completion of the study“, says Dr. Alessandro Michelucci, the third main author of the study.

“Our observations are important, on the one hand, for paving the way for the discovery of novel therapeutic opportunities to combat neurodegeneration“, says Dr. Manuel Buttini, “and, on the other hand, for the development of new drugs to fight diseases such as Parkinson’s or Alzheimer’s. Indeed, by analysing metabolite profiles rather than just microscopic cellular changes or individual biomolecules, a better understanding of the effect of novel therapeutics for brain diseases should be feasible.“

Weitere Informationen:

http://www.sciencedirect.com/science/article/pii/S0002944015001509 - Link to the scientic publication
http://www.lcsb.lu - Homepage of the Luxembourg Centre for Systems Biomedicine

Britta Schlüter | Universität Luxemburg - Université du Luxembourg

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>