Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Important molecule discovered for the self-renewal of blood stem cells

19.06.2015

Blood stem cells constitute the only lifelong source for the billions of new blood cells produced every day in our body. Since their number is rather very small, maintencance of these stem cells by their capacity to self-renew represents a vital prerequisite for a functional blood and immune system.

Unfortunately, the molecular mechanisms of stem cell self-renewal remain elusive, although a great therapeutical need exists for these cells to be used in stem cell transplantations to treat cancer and blood diseases. This need could be covered by effective expansion of blood stem cells in cell culture, while preserving their full stem cell capacity.

The groups of Martin Zörnig at the Georg-Speyer-Haus in Frankfurt and Michael Rieger at the University Clinic Frankfurt (LOEWE Center for Cell and Gene Therapy and Department of Hematology/Oncology) joined forces and identified the molecule FUSE Binding Protein 1 (FUBP1) as an essential factor for the self-renewal of blood stem cells in a close collaboration.

FUBP1 functions as a transcriptional regulator, which binds to its single-stranded target DNA sequence FUSE upstream of target genes that are activated or repressed upon FUBP1 binding. As a consequence, a whole network of genes is controlled by FUBP1.

Among others, FUBP1 represses the cell cycle inhibitor p21 and the cell death-inducing molecule Noxa, thereby supporting the survival and expansion of the stem cells. Interestingly, FUBP1 is absolutely essential for both, the expansion of blood stem cells during early embryonic development and for their lifelong production in the adult organism. The results of this study are now published in the internationally recognized journal "Cell Reports" (see link below).

Future studies address the question which molecular signal transduction pathways in stem cells are regulated by FUBP1, and how they can be manipulated to improve an efficient blood stem cell expansion in cell culture for therapeutic stem cell transplantations. In additon, the GSH researchers started to investigate whether FUBP1 represents a promising target molecule for cancer therapy to inhibit the fatal self-renewal of cancer stem cells.

Publication:
Rabenhorst, U.*, Thalheimer, F.B.*, Gerlach, K.*, Kijonka, M., Böhm, S., Krause, D., Vauti, F., Arnold, HH., Schroeder, T., Schnütgen, F., von Melchner, H., Rieger, M.A.#, and Zörnig, M.# "Single-stranded DNA-binding transcriptional regulator FUBP1 is essential for fetal and adult hematopoietic stem cell self-renewal."
Cell Reports 11:1-9 (2015)
* equal first authors
# shared senior authorship

Contact:
Prof. Dr. Martin Zörnig
Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy
Paul-Ehrlich-Straße 42-44
60596 Frankfurt, Germany
Telefon: 069/63395-115
E-Mail: zoernig@gsh.uni-frankfurt.de

Weitere Informationen:

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00610-5

Christine Kost | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>