Blood stem cells constitute the only lifelong source for the billions of new blood cells produced every day in our body. Since their number is rather very small, maintencance of these stem cells by their capacity to self-renew represents a vital prerequisite for a functional blood and immune system.
Unfortunately, the molecular mechanisms of stem cell self-renewal remain elusive, although a great therapeutical need exists for these cells to be used in stem cell transplantations to treat cancer and blood diseases. This need could be covered by effective expansion of blood stem cells in cell culture, while preserving their full stem cell capacity.
The groups of Martin Zörnig at the Georg-Speyer-Haus in Frankfurt and Michael Rieger at the University Clinic Frankfurt (LOEWE Center for Cell and Gene Therapy and Department of Hematology/Oncology) joined forces and identified the molecule FUSE Binding Protein 1 (FUBP1) as an essential factor for the self-renewal of blood stem cells in a close collaboration.
FUBP1 functions as a transcriptional regulator, which binds to its single-stranded target DNA sequence FUSE upstream of target genes that are activated or repressed upon FUBP1 binding. As a consequence, a whole network of genes is controlled by FUBP1.
Among others, FUBP1 represses the cell cycle inhibitor p21 and the cell death-inducing molecule Noxa, thereby supporting the survival and expansion of the stem cells. Interestingly, FUBP1 is absolutely essential for both, the expansion of blood stem cells during early embryonic development and for their lifelong production in the adult organism. The results of this study are now published in the internationally recognized journal "Cell Reports" (see link below).
Future studies address the question which molecular signal transduction pathways in stem cells are regulated by FUBP1, and how they can be manipulated to improve an efficient blood stem cell expansion in cell culture for therapeutic stem cell transplantations. In additon, the GSH researchers started to investigate whether FUBP1 represents a promising target molecule for cancer therapy to inhibit the fatal self-renewal of cancer stem cells.
Rabenhorst, U.*, Thalheimer, F.B.*, Gerlach, K.*, Kijonka, M., Böhm, S., Krause, D., Vauti, F., Arnold, HH., Schroeder, T., Schnütgen, F., von Melchner, H., Rieger, M.A.#, and Zörnig, M.# "Single-stranded DNA-binding transcriptional regulator FUBP1 is essential for fetal and adult hematopoietic stem cell self-renewal."
Cell Reports 11:1-9 (2015)
* equal first authors
# shared senior authorship
Prof. Dr. Martin Zörnig
Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy
60596 Frankfurt, Germany
Christine Kost | idw - Informationsdienst Wissenschaft
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy