Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Important molecule discovered for the self-renewal of blood stem cells

19.06.2015

Blood stem cells constitute the only lifelong source for the billions of new blood cells produced every day in our body. Since their number is rather very small, maintencance of these stem cells by their capacity to self-renew represents a vital prerequisite for a functional blood and immune system.

Unfortunately, the molecular mechanisms of stem cell self-renewal remain elusive, although a great therapeutical need exists for these cells to be used in stem cell transplantations to treat cancer and blood diseases. This need could be covered by effective expansion of blood stem cells in cell culture, while preserving their full stem cell capacity.

The groups of Martin Zörnig at the Georg-Speyer-Haus in Frankfurt and Michael Rieger at the University Clinic Frankfurt (LOEWE Center for Cell and Gene Therapy and Department of Hematology/Oncology) joined forces and identified the molecule FUSE Binding Protein 1 (FUBP1) as an essential factor for the self-renewal of blood stem cells in a close collaboration.

FUBP1 functions as a transcriptional regulator, which binds to its single-stranded target DNA sequence FUSE upstream of target genes that are activated or repressed upon FUBP1 binding. As a consequence, a whole network of genes is controlled by FUBP1.

Among others, FUBP1 represses the cell cycle inhibitor p21 and the cell death-inducing molecule Noxa, thereby supporting the survival and expansion of the stem cells. Interestingly, FUBP1 is absolutely essential for both, the expansion of blood stem cells during early embryonic development and for their lifelong production in the adult organism. The results of this study are now published in the internationally recognized journal "Cell Reports" (see link below).

Future studies address the question which molecular signal transduction pathways in stem cells are regulated by FUBP1, and how they can be manipulated to improve an efficient blood stem cell expansion in cell culture for therapeutic stem cell transplantations. In additon, the GSH researchers started to investigate whether FUBP1 represents a promising target molecule for cancer therapy to inhibit the fatal self-renewal of cancer stem cells.

Publication:
Rabenhorst, U.*, Thalheimer, F.B.*, Gerlach, K.*, Kijonka, M., Böhm, S., Krause, D., Vauti, F., Arnold, HH., Schroeder, T., Schnütgen, F., von Melchner, H., Rieger, M.A.#, and Zörnig, M.# "Single-stranded DNA-binding transcriptional regulator FUBP1 is essential for fetal and adult hematopoietic stem cell self-renewal."
Cell Reports 11:1-9 (2015)
* equal first authors
# shared senior authorship

Contact:
Prof. Dr. Martin Zörnig
Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy
Paul-Ehrlich-Straße 42-44
60596 Frankfurt, Germany
Telefon: 069/63395-115
E-Mail: zoernig@gsh.uni-frankfurt.de

Weitere Informationen:

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00610-5

Christine Kost | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
21.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New bioimaging technique is fast and economical

21.08.2017 | Medical Engineering

Silk could improve sensitivity, flexibility of wearable body sensors

21.08.2017 | Materials Sciences

On the way to developing a new active ingredient against chronic infections

21.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>