Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

IL-34: a new, possible target to tackle drug-resistant cancer cells

04.10.2016

A team of researchers has discovered that chemoresistant lung cancer cells suppress immune functions and strengthen resistance to chemotherapy by producing interleukin-34 (IL-34)—a type of cytokine.

Chemotherapy is one of the most important treatments for many cancer patients. In recent years, chemotherapies that target the immune system have been developed, resulting in remarkable advances in cancer treatments. However, the ability of tumor cells to escape immune destruction and acquire resistance to chemotherapy remain major obstacles to effective cancer therapy.


Expression of IL-34 (brown) in human primary lung adenocarcinoma tissue. IL-34 expression correlated with poor prognosis in cancer patients and was found to enhance local immunosuppression by tumor-associated macrophages, and also provides cancer cells with a critical survival signal to overcome chemotherapeutic conditions. (Baghdadi M. et. al., Sep 30, 2016, Cancer Research)


Chemoresistant cancer cells secrete IL-34, which induces production of immunosuppressive macrophages and enhances chemoresistance of the cancer cells.

It is known that immunosuppressive macrophages accumulate at tumor sites where the tumor cells have become resistant to chemotherapy. Assistant Professor Muhammad Baghdadi, Lecturer Haruka Wada and Professor Ken-ichiro Seino of the Division of Immunobiology at Hokkaido University’s Institute for Genetic Medicine, conducted research with collaborators based on a theory that chemoresistant tumor cells produce an unidentified substance that increases tumor-associated macrophages, thus enhancing their resistance to chemotherapy.

In the latest research, the team cultivated chemosensitive A549-DS, made from A549 lung cancer cells, together with the chemotherapeutic drug doxorubicin, to create doxorubicin-resistant A549-DR. The researchers examined the two cells, finding a large amount of IL-34 was produced in the A549-DR, but not in the A549-DS.

They also found that the IL-34 produced by A549-DR contributed to the production of immunosuppressive macrophages. Furthermore, their experiment showed that IL-34 enhanced the chemoresistance of A549-DR.

In experiments using mice, researchers found that A549-DR was resistant to the chemotherapeutic drug when transplanted in mice, while A549-DR with depleted IL-34 became sensitive to the same drug, suggesting that IL-34 enhanced chemoresistance in the animal body.

Furthermore, researchers discovered high levels of IL-34 in tumors removed from several lung cancer patients. They also examined the prognoses of post-operative patients—studying those with, and those without IL-34 in their tumors, finding that the former’s prognoses were poorer than the latter’s.

“Currently, there are only a few options to treat chemoresistant tumors.,” Professor Seino said. “This latest finding could make it possible to develop a new therapy, which targets IL-34, to treat chemoresistant cancer cells”.

The research was jointly conducted with Kanagawa Cancer Center, Shiga University of Medical Science, and the University of Tokyo.

Contacts:
Professor Ken-ichiro Seino
Division of Immunobiology, Institute for Genetic Medicine
Hokkaido University
seino[at]igm.hokudai.ac.jp

Naoki Namba (Media Officer)
Global Relations Office
Office of International Affairs
Hokkaido University
pr[at]oia.hokudai.ac.jp>

Associated links

Journal information

Baghdadi M. et. al., Chemotherapy-induced IL-34 enhances immunosuppression by tumor-associated macrophages and mediates survival of chemoresistant lung cancer cells. Sep 30, 2016, Cancer Research. DOI: 10.1158/0008-5472
http://cancerres.aacrjournals.org/content/early/2016/09/29/0008-5472.CAN-16-1170

Hokkaido University | Research SEA

More articles from Life Sciences:

nachricht Bare bones: Making bones transparent
27.04.2017 | California Institute of Technology

nachricht Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Bare bones: Making bones transparent

27.04.2017 | Life Sciences

Study offers new theoretical approach to describing non-equilibrium phase transitions

27.04.2017 | Physics and Astronomy

From volcano's slope, NASA instrument looks sky high and to the future

27.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>