Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Identifying drug targets for leukaemia

02.05.2016

Researchers from Hong Kong and the U.S. have developed a new statistical and mapping method that could help identify drug targets for treating leukaemia.

In chronic myelogenous leukaemia (CML), too many stem cells in the bone marrow are transformed into a type of white blood cell called granulocytes, making less room for healthy white blood cells, red blood cells and platelets. CML occurs due to a chromosomal abnormality in which an abnormal gene is formed, called the BCR-ABL fusion gene. However, the development of CML is not fully understood, leading to limited treatment options.


The findings could help physicians develop more effective treatment strategies for chronic myelogenous leukaemia.

Copyright : Sebastian Kaulitzki

The BCR-ABL gene activates enzyme pathways that disrupt protein synthesis and cause uncontrolled cell growth. A better understanding of these pathways and how they are activated could lead to the discovery of drug targets for CML.

Past research has shown that the expression of a protein-coding gene called NPM1 changes in tumour cells. NPM1 was found to respond to signals from enzyme pathways initiated by the BCR-ABL gene.

Benjamin Yung’s research group at The Hong Kong Polytechnic University together with researchers from Harvard University in the U.S. and Queen Elizabeth Hospital in Hong Kong have developed a unique statistical and mapping strategy that identifies the relationships among those genes that are involved in the development of CML.

Using their unique statistical approach, the researchers quantified and analysed publicly available gene expression data of nine CML patients and eight healthy volunteers. They created networking maps from the data to facilitate the visualization of the connections among genes.

They compared NPM1 gene expressions with those from the BCR-ABL-initiated enzyme pathways in the CML patients and similar pathways that exist in healthy individuals. They also explored the role of NPM1 “doublets” – genes strongly co-expressed with NPM1 – in protein formation.

The researchers identified two sets of gene doublets that strongly co-expressed in CML patients but were not co-expressed in healthy individuals. These gene pairs may be related to CML development and thus could be an important target for drug research.

They also found that NPM1 established ten gene-expressing pairs with BCR-ABL pathways in CML patients but only two pairs with similar pathways in healthy individuals, which may mean that NPM1 mediates the activation of other cellular proliferation pathways in CML.

Finally, the researchers used a substance, called resveratrol, which is thought to have anti-cancer properties, on CML cells. Resveratrol caused a decrease in the expression of NPM1-related proteins and is thus a potential drug target for CML therapy.

The researchers’ findings could help physicians develop more effective treatment strategies for CML. Their statistical and mapping strategy can also be used to diagnose and develop treatments for other diseases.

For further information contact:

Professor Benjamin Yung
Department of Health Technology and Informatics
The Hong Kong Polytechnic University
E-mail: ben.yung@polyu.edu.hk

Associated links

The Hong Kong Polytechnic University | Research SEA
Further information:
http://www.researchsea.com

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

DGIST develops 20 times faster biosensor

24.04.2017 | Physics and Astronomy

Nanoimprinted hyperlens array: Paving the way for practical super-resolution imaging

24.04.2017 | Materials Sciences

Atomic-level motion may drive bacteria's ability to evade immune system defenses

24.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>