Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Identifying drug targets for leukaemia

02.05.2016

Researchers from Hong Kong and the U.S. have developed a new statistical and mapping method that could help identify drug targets for treating leukaemia.

In chronic myelogenous leukaemia (CML), too many stem cells in the bone marrow are transformed into a type of white blood cell called granulocytes, making less room for healthy white blood cells, red blood cells and platelets. CML occurs due to a chromosomal abnormality in which an abnormal gene is formed, called the BCR-ABL fusion gene. However, the development of CML is not fully understood, leading to limited treatment options.


The findings could help physicians develop more effective treatment strategies for chronic myelogenous leukaemia.

Copyright : Sebastian Kaulitzki

The BCR-ABL gene activates enzyme pathways that disrupt protein synthesis and cause uncontrolled cell growth. A better understanding of these pathways and how they are activated could lead to the discovery of drug targets for CML.

Past research has shown that the expression of a protein-coding gene called NPM1 changes in tumour cells. NPM1 was found to respond to signals from enzyme pathways initiated by the BCR-ABL gene.

Benjamin Yung’s research group at The Hong Kong Polytechnic University together with researchers from Harvard University in the U.S. and Queen Elizabeth Hospital in Hong Kong have developed a unique statistical and mapping strategy that identifies the relationships among those genes that are involved in the development of CML.

Using their unique statistical approach, the researchers quantified and analysed publicly available gene expression data of nine CML patients and eight healthy volunteers. They created networking maps from the data to facilitate the visualization of the connections among genes.

They compared NPM1 gene expressions with those from the BCR-ABL-initiated enzyme pathways in the CML patients and similar pathways that exist in healthy individuals. They also explored the role of NPM1 “doublets” – genes strongly co-expressed with NPM1 – in protein formation.

The researchers identified two sets of gene doublets that strongly co-expressed in CML patients but were not co-expressed in healthy individuals. These gene pairs may be related to CML development and thus could be an important target for drug research.

They also found that NPM1 established ten gene-expressing pairs with BCR-ABL pathways in CML patients but only two pairs with similar pathways in healthy individuals, which may mean that NPM1 mediates the activation of other cellular proliferation pathways in CML.

Finally, the researchers used a substance, called resveratrol, which is thought to have anti-cancer properties, on CML cells. Resveratrol caused a decrease in the expression of NPM1-related proteins and is thus a potential drug target for CML therapy.

The researchers’ findings could help physicians develop more effective treatment strategies for CML. Their statistical and mapping strategy can also be used to diagnose and develop treatments for other diseases.

For further information contact:

Professor Benjamin Yung
Department of Health Technology and Informatics
The Hong Kong Polytechnic University
E-mail: ben.yung@polyu.edu.hk

Associated links

The Hong Kong Polytechnic University | Research SEA
Further information:
http://www.researchsea.com

More articles from Life Sciences:

nachricht Antimicrobial substances identified in Komodo dragon blood
23.02.2017 | American Chemical Society

nachricht New Mechanisms of Gene Inactivation may prevent Aging and Cancer
23.02.2017 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>