Researchers reveal how cells protect themselves from a protein that is a key driver of cancer. The study appears in The Journal of Cell Biology.
Mutations that activate a protein called Ras drive excessive cell proliferation associated with cancer, but their ability to promote tumor growth is limited by the fact that they also induce cells to exit the cell cycle and become dormant, or senescent.
How active Ras mutants induce senescence, and how this pathway is disrupted in cancer cells is still unclear.
Geoffrey Clark and colleagues from the University of Louisville examined the role of the tumor suppressor NORE1A, a protein that binds to active Ras. Overexpressing NORE1A induced cell senescence, whereas removing the protein prevented senescence and enhanced the transformation of cells with cancer-promoting Ras mutations.
The researchers found that Ras enhanced NORE1A’s association with a kinase called HIPK2, and that this interaction was required for cell senescence.
NORE1A promoted HIPK2’s association with p53, a tumor suppressor that plays a major role in restricting cancer development. HIPK2 is known to modify p53 in ways that cause either apoptosis, a kind of cell suicide, or senescence. Clark and colleagues found that NORE1A enhanced the senescence pathway.
The findings delineate how NORE1A allows Ras to modulate p53 function and induce cell senescence, and the loss of NORE1A may be a critical step in the growth of tumors.
Donninger, H., et al. 2015. J. Cell Biol. doi:10.1083/jcb.201408087
About The Journal of Cell Biology
The Journal of Cell Biology (JCB) is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editors. JCB content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works, and third parties may reuse the content for non-commercial purposes under a creative commons license.
For more information, please visit www.jcb.org
Research reported in the press release was supported by the National Institutes of Health.
Rita Sullivan King
Rita Sullivan King | newswise
The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences
Transforming plant cells from generalists to specialists
07.12.2016 | Duke University
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
07.12.2016 | Health and Medicine
07.12.2016 | Life Sciences
07.12.2016 | Health and Medicine