Researchers from Dresden and Leipzig have jointly developed and tested a set of hydrogel wound dressings based on glycosaminoglycans. The hydrogels allow for the reduction of inflammatory reactions in ways that promise new treatment modalities for patients suffering from chronic cutaneous wounds.
Diabetes, a globally prevalent medical condition with more than 420 million affected patients, is often associated with chronic wounds whose treatment remains challenging.
Researchers at the Leibniz Institute of Polymer Research Dresden and the Department of Dermatology of the University of Leipzig have now jointly developed and tested a set of hydrogel wound dressings based on glycosaminoglycans, a class of naturally occurring carbohydrates.
The hydrogels allow for the reduction of inflammatory reactions in ways that promise new treatment modalities for patients suffering from chronic cutaneous wounds.
Collaborating within the Coordinated Research Center “Functional biomaterials for controlling healing processes in bone and skin” of the German Research Foundation, the interdisciplinary team explored a new approach to neutralize pro-inflammatory chemokines, signaling proteins that trigger the migration of immune cells into skin wounds.
Employing biomolecular interactions, the engineered hydrogels were shown to effectively bind and inactivate pro-inflammatory chemokines.
As reported in the current issue of Science Translational Medicine and highlighted with the cover image, the novel wound dressings accelerated cutaneous healing in a diseased animal model.
Further testing of the promising materials may pave the way for a potential future application in human patients. Beyond that, the underlying concept is expected to be similarly applicable in the treatment of other disorders associated with pathologically enhanced inflammatory reactions.
N. Lohmann, L. Schirmer, P. Atallah, E. Wandel, R. A. Ferrer, C. Werner, J. C. Simon, S. Franz, U. Freudenberg, Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice.
Sci. Transl. Med. 9, eaai9044 (2017).
Sandra Franz, firstname.lastname@example.org, +49 341-9725880
Uwe Freudenberg, email@example.com, + 49 351-4658 408
Kerstin Wustrack | idw - Informationsdienst Wissenschaft
More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
19.01.2018 | Materials Sciences
19.01.2018 | Health and Medicine
19.01.2018 | Physics and Astronomy