Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Glycosaminoglycan-based hydrogels for a better treatment of chronic wounds

20.04.2017

Researchers from Dresden and Leipzig have jointly developed and tested a set of hydrogel wound dressings based on glycosaminoglycans. The hydrogels allow for the reduction of inflammatory reactions in ways that promise new treatment modalities for patients suffering from chronic cutaneous wounds.

Diabetes, a globally prevalent medical condition with more than 420 million affected patients, is often associated with chronic wounds whose treatment remains challenging.

Researchers at the Leibniz Institute of Polymer Research Dresden and the Department of Dermatology of the University of Leipzig have now jointly developed and tested a set of hydrogel wound dressings based on glycosaminoglycans, a class of naturally occurring carbohydrates.

The hydrogels allow for the reduction of inflammatory reactions in ways that promise new treatment modalities for patients suffering from chronic cutaneous wounds.

Collaborating within the Coordinated Research Center “Functional biomaterials for controlling healing processes in bone and skin” of the German Research Foundation, the interdisciplinary team explored a new approach to neutralize pro-inflammatory chemokines, signaling proteins that trigger the migration of immune cells into skin wounds.

Employing biomolecular interactions, the engineered hydrogels were shown to effectively bind and inactivate pro-inflammatory chemokines.

As reported in the current issue of Science Translational Medicine and highlighted with the cover image, the novel wound dressings accelerated cutaneous healing in a diseased animal model.

Further testing of the promising materials may pave the way for a potential future application in human patients. Beyond that, the underlying concept is expected to be similarly applicable in the treatment of other disorders associated with pathologically enhanced inflammatory reactions.

N. Lohmann, L. Schirmer, P. Atallah, E. Wandel, R. A. Ferrer, C. Werner, J. C. Simon, S. Franz, U. Freudenberg, Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice.
Sci. Transl. Med. 9, eaai9044 (2017).
DOI: 10.1126/scitranslmed.aai9044

Weitere Informationen:

http://stm.sciencemag.org/content/9/386/eaai9044

Contact:
Sandra Franz, sandra.franz@medizin.uni-leipzig.de, +49 341-9725880
Uwe Freudenberg, freudenberg@ipfdd.de, + 49 351-4658 408

Kerstin Wustrack | idw - Informationsdienst Wissenschaft
Further information:
http://www.ipfdd.de

More articles from Life Sciences:

nachricht Multifunctional bacterial microswimmer able to deliver cargo and destroy itself
26.04.2018 | Max-Planck-Institut für Intelligente Systeme

nachricht ADP-ribosylation on the right track
26.04.2018 | Max-Planck-Institut für Biologie des Alterns

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

European particle-accelerator community publishes the first industry compendium

26.04.2018 | Physics and Astronomy

Multifunctional bacterial microswimmer able to deliver cargo and destroy itself

26.04.2018 | Life Sciences

Why we need erasable MRI scans

26.04.2018 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>