Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Game Theory Explains Social Interactions of Cancer Cells

28.01.2015

Researchers at the University of Basel and the University of East Anglia were able to predict the interactions of cancer cells using game theory. Their results have been published by the scientific journal PNAS.

A tumor consists of a heterogeneous population of individual cells that compete for space and nutrients against each other. However, cancer cells also cooperate in their struggle for survival by sharing molecules, such as growth factors.


Public goods game network: Colorless cancer cells that do not produce IGF-II but need it for their growth reproduce in a population of green cancer cells that produces and consumes IGF-II.

University of Basel, Daniela Ferarro

Cells that do not produce growth factors themselves have a proliferation advantage because they can use the factors produced by neighboring cells without the cost of producing them. What maintains this cooperation between tumor cells remains an open question and continues to obstruct medical therapies that target tumor growth.

Free riding cancer cells

The Public Goods Game is part of game theory and is used in economics as a model to analyze the provision of common goods. There is an imbalance in the consumption of these goods between those that provide them and pay the production costs and those that do not pay but consume anyway - a situation that is known in economics as the free rider problem.

The researchers now applied this model to the cooperation between producing and non-producing members of a cancer cell population, in order to examine if the model is also applicable to biological processes, such as carcinogenesis.

Using computer simulations, the researchers were able to calculate the long-term equilibrium between producing cells and “free riding” cells. They then used experiments with pancreatic cancer cells to test their calculations. Their results were in line with the predictions of the game theory model.

“Besides the finding that biological processes can be predicted by using computer simulations, our results suggest that further work on the 'social' interactions among cancer cells may reveal further insight into the dynamics of cancer, and hopefully guide research toward evolutionary stable therapies”, says Gerhard Christofori, Professor at the Department of Biomedicine of the University of Basel.

Original source
Marco Archetti, Daniela A. Ferraro, Gerhard Christofori
Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer
PNAS | doi: 10.1073/pnas.1414653112

Further information
Prof. Dr. Gerhard Christofori, Department of Biomedicine,University of Basel, phone: +41 61 267 35 62, email: gerhard.christofori@unibas.ch

Weitere Informationen:

http://www.pnas.org/content/early/2015/01/21/1414653112.abstract - Abstract

Reto Caluori | Universität Basel
Further information:
http://www.unibas.ch

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>