The consortium led by Leiden University Medical Center and the Dutch hDMT (human Disease Model Technologies) has been assigned by the EU with the task to create a roadmap for the future development of organ-on-chip technology. Its aim is to establish a European infrastructure to enable coordinated development, production and implementation of organ-on-a-chip systems. The consortium is funded by the EU FET-Open Program and brings together six leading European research institutions, including the Fraunhofer-Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart, Germany.
The consortium’s aim is to accelerate the societal and economic impact of organ-on-a-chip technology through coordinated action. Organs-on-chips combine human mini-organs with microelectronics, microfluidics and nanosensors.
This technology is already providing new platforms for drug discovery but is poised to deliver applications in personalized medicine and safety pharmacology, and offers alternatives to conventional animal testing. Over the next two years, the EU will invest 0.5 million Euros in the ORgan-on-CHip In Development (ORCHID) project.
ORCHID will facilitate dialogue and documentation towards accelerating the development of prototypes of organs-on-chips, validated cell systems that mimic diseased or healthy human tissue, and implementation of this technology by a broad group of potential users in science, health care and industry.
Within the consortium, the Fraunhofer IGB will focus on the economic and educational aspects of the ORCHID project. Dr. Peter Loskill, head of the institute’s research group on organ-on-a-chip systems, and his team will evaluate which skills are essential for the development and application of organ-on-a-chip technology.
On this basis, it is possible to identify specific training contents for the further education of researchers, developers, and users. A further task of Dr. Loskill and his team will be the assessment of suitable business models for the commercialization of organ-on-a-chip systems, taking advantage of the extensive economic expertise of the Fraunhofer IGB as an application-oriented research institute.
Ultimately, ORCHID will build an infrastructure for scientists, policy makers, funders and end-users to join the decision-making processes that will direct future European developments in organ-on-a-chip applications. An essential contribution of ORCHID will be the establishment of a digital platform enabling knowledge sharing between researchers and representatives of private corporations including insurance companies, pharmaceutical and biotech companies, food industry, health foundations and patient organizations.
The ORCHID platform will provide overviews and updates of current and new organ-on-a-chip initiatives so that users can track progress easily, consult developers directly and identify gaps in present knowledge, limiting implementation. ORCHID will also address ethical and regulatory issues, particularly concerning personalized information, economic and societal impact, training of researchers, and the design of an R&D roadmap.
The consortium is composed of the following organizations:
- Leiden University Medical Center, the Netherlands; coordinator contact: Christine Mummery, PhD, Professor of Developmental Biology, Chair Dept. of Anatomy
- Organ-on-Chip consortium hDMT, the Netherlands; strategy and the roadmap contact: Janny van den Eijnden van Raaij, PhD, Managing director
- Fraunhofer IGB, Germany; Peter Loskill, PhD, Attract Group Manager Organ-on-a-chip, Department of Cell and Tissue Engineering
- CEA LETI, France; eco-system development and the digital platform contact: Adrienne Pervès PhD, Deputy Head of Department-LETI-Technologies for biology and health
- Imec, Belgium; ethical aspects, regulation and standardization contact: Wolfgang Eberle, PhD, Funded Program Manager Smart Health and NERF Coordinator EIT Health
- University of Zaragoza, Spain; dissemination contact: Luis Fernandez, PhD, Professor Mechanical Engineering, Dept. of Applied Mechanics and Bioengineering
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 766884
Dr. Claudia Vorbeck | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
Rochester scientists discover gene controlling genetic recombination rates
23.04.2018 | University of Rochester
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
23.04.2018 | Physics and Astronomy
23.04.2018 | Physics and Astronomy
23.04.2018 | Trade Fair News