Biologists who study the malaria mosquito's 'nose' have found that it contains a secondary set of odor sensors that seem to be specially tuned to detect humans. The discovery could aid efforts to figure out how the insects target humans and develop a preference for them.
If you could peer into the mind of a female mosquito, you would find that her world is dominated by smell rather than sight or sound.
She follows whiffs of carbon dioxide exhaled by animals to locate potential prey. As she closes in on a target, she uses the animal's body odors to decide whether it is a desirable host. After getting the blood meal she needs to reproduce, she follows the scent of stagnant water to find a place to lay her eggs.
Her delicate antennae, proboscis and a pair of mouth appendages called palps are what make this possible. They are covered by tiny hollow sensory hairs called sensilla that are filled with an impressive array of odor sensors that can discriminate among thousands of different aromatic compounds.
For the last 15 years, a team of biologists at Vanderbilt University have been studying a family of 79 odorant receptors (ORs) in the malaria mosquito (Anopheles gambiae) in hopes of finding better repellents and lures that can be used to prevent the spread of malaria and other mosquito-borne diseases.
As the researchers meticulously determined the specific compounds that triggered these receptors, however, they were surprised to discover that the Anopheles ORs did not respond to many of the smelly human odors that they know mosquitoes can detect.
The scientists think they now have a handle on at least one of the reasons for this disparity. In a paper published earlier this year in the journal Scientific Reports they report that the malaria mosquito has a second complete system of odor sensors - discovered five years ago in the fruit fly (Drosphila melanogaster) - that are specially tuned to at least two human-derived chemical signals, which the insect's OR system cannot detect. So adult females use this second system of odor sensors to seek human prey.
"This appears to be a more primitive olfactory system and one which Anopheles uses to detect humans," said Cornelius Vanderbilt Professor of Biological Sciences Laurence Zwiebel, who directed the study. "It fills important gaps in the mosquito's chemosensory perception that are not provided by the OR system."
In a series of extensive and painstaking experiments carried out for his senior honors thesis, undergraduate Stephen L. Derryberry (now a student at the Vanderbilt School of Medicine), along with Research Assistant Professor Jason Pitts, succeeded in functionally characterizing three of these different sensors, called ionotropic receptors (IRs), in Anopheles. The researchers determined that unique combinations of IRs respond to two classes of compounds found in human sweat: carboxylic acids that impart a vinegary tang and ammonia derivatives called amines.
"Stephen's project was more difficult than simply searching for a needle in a haystack," Zwiebel said. "It was more like searching for a needle in a HUGE haystack, because we had no idea of what odorant molecules would trigger the IR system. Even worse, we didn't know what combinations of IR receptors might be involved." (In flies IRs only detect target molecules in conjunction with co-receptors on the same neuron.)
There is still a great deal about the IR system that the scientists don't understand. For example, they think the mosquitoes may also use this ancient family of proteins to detect infrared radiation and humidity levels.
One measure of the importance of an olfactory system is the number of connections it has to the brain. By this measure the OR system is the most important because it has more neurons that link it to the mosquito's brain, but the IR system runs a close second.
"The mosquito is an extremely sophisticated organism," said Pitts. "They use a combination of finely tuned olfactory systems to locate their prey. We have now found two of these systems, but, based on what we know about the mosquito's genome, we think there are others that we haven't identified yet."
"Despite all the research we have done, we still haven't fully figured out how mosquitoes identify and, even more importantly, develop a preference for humans," Zwiebel observed.
The research was supported by National Institutes of Health grant AI056402.
David F Salisbury | EurekAlert!
New catalyst controls activation of a carbon-hydrogen bond
21.11.2017 | Emory Health Sciences
The main switch
21.11.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
21.11.2017 | Physics and Astronomy
21.11.2017 | Physics and Astronomy
21.11.2017 | Life Sciences