Kyoto University shows how fish oil can improve fat metabolism in mice
Researchers have found that fish oil transforms fat-storage cells into fat-burning cells, which may reduce weight gain in middle age.
Kyoto University researchers have found that fish oil transforms fat-storage cells into fat-burning cells, which may reduce weight gain in middle age. Fish oil activates receptors in the digestive tract, fires the sympathetic nervous system, and induces storage cells to metabolize fat.
Credit: Eiri Ono/Kyoto University
The team explains in Scientific Reports that fish oil activates receptors in the digestive tract, fires the sympathetic nervous system, and induces storage cells to metabolize fat.
Fat tissues don't all store fat. So-called "white" cells store fat in order to maintain energy supply, while "brown" cells metabolize fat to maintain a stable body temperature. Brown cells are abundant in babies but decrease in number with maturity into adulthood.
A third type of fat cell -- "beige" cells -- have recently been found in humans and mice, and have shown to function much like brown cells. Beige cells also reduce in number as people approach middle age; without these metabolizing cells, fat continues accumulating for decades without ever being used.
The scientists investigated whether the number of these beige cells could be increased by taking in certain types of foods.
"We knew from previous research that fish oil has tremendous health benefits, including the prevention of fat accumulation," says senior author Teruo Kawada. "We tested whether fish oil and an increase in beige cells could be related."
The team fed a group of mice fatty food, and other groups fatty food with fish oil additives. The mice that ate food with fish oil, they found, gained 5-10% less weight and 15-25% less fat compared to those that did not consume the oil.
They also found that beige cells formed from white fat cells when the sympathetic nervous system was activated, meaning that certain fat-storage cells acquired the ability to metabolize.
"People have long said that food from Japan and the Mediterranean contribute to longevity, but why these cuisines are beneficial was up for debate," adds Kawada. "Now we have better insight into why that may be."
The paper "Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system" will appear 17 December 2015 in Scientific Reports, with doi: 10.1038/srep18013
Kyoto University is one of Japan and Asia's premier research institutions, founded in 1897 and responsible for producing numerous Nobel laureates and winners of other prestigious international prizes. A broad curriculum across the arts and sciences at both undergraduate and graduate levels is complemented by numerous research centers, as well as facilities and offices around Japan and the world. For more information please see: http://www.
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