Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Fish Oil-Diet Benefits May be Mediated by Gut Microbes


Diets rich in fish oil versus diets rich in lard produce very different bacteria in the guts of mice, reports a study from Sahlgrenska Academy published in Cell Metabolism. The researchers transferred these microbes into other mice to see how they affected health. The results suggest that gut bacteria share some of the responsibility for the beneficial effects of fish oil and the harmful effects of lard.

In particular, mice that received transplants of gut microbes associated with a fish oil diet were protected against diet-induced weight gain and inflammation compared with mice transplanted with gut microbes associated with a lard diet. This demonstrates that gut microbes are an independent factor aggravating inflammation associated with diet-induced obesity and gives hope that a probiotic might help counteract a "greasy" diet.

Fish Oil-Diet Benefits May be Mediated by Gut Microbes

University of Gothenburg

Interventions for optimizing health

"We wanted to determine whether gut microbes directly contribute to the metabolic differences associated with diets rich in healthy and unhealthy fats," says first study author Robert Caesar of the University of Gothenburg. Even though the study was done in mice, "our goal is to identify interventions for optimizing metabolic health in humans."

Monitoring the metabolics

Caesar, working in the lab of senior study author Fredrik Bäckhed, began by feeding either lard or fish oil to mice for 11 weeks and monitoring signs of metabolic health.

While the consumption of lard promoted the growth of bacteria called Bilophila, which have been linked to gut inflammation, the fish oil diet increased the abundance of bacteria called Akkermansia muciniphila, known to reduce weight gain and improve glucose metabolism in mice.

"We were surprised that the lard and the fish oil diet, despite having the same energy content and the same amount of dietary fiber--which is the primary energy source for the gut bacteria--resulted in fundamentally different gut microbiota communities and that the microbiota per se had such large effects on health," says Fredrik Bäckhed.

Additional evidence

In the next set of experiments, the researchers conducted "fecal transplants" to test whether fish oil-diet microbes could improve the health of mice fed only lard and vice versa. The results provide additional evidence that gut microbe communities can both determine and recover health problems caused by poor diet.

"Our paper supports previous reports indicating the bacteria Akkermansia muciniphila is a promoter of a healthy phenotype," Bäckhed says. "However, further investigations will be needed to determine if this bacteria can be used as probiotic strain and, in that case, how it should be combined with diet to optimize health outcomes."

The paper "Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling" was published in Cell Metabolism 27 August.

Link to journal:

For more information please contact:

Fredrik Bäckhed, Professor at Sahlgrenska Academy, University of Gothenburg
+46 (0)31-342 7833
+46 (0)70-2182355

Robert Caesar, researcher at the Sahlgrenska Academy, University of Gothenburg
Phone: +46 (0)31-342 8672

Weitere Informationen:

Henrik Axlid | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>