On 25 and 26 January the CCHFVaccine kick-off meeting took place at the Paul-Ehrlich-Institut. CCHFVaccine is a multinational and interdisciplinary research project. This consortium will investigate model vaccines against Crimean-Congo haemorrhagic fever for the protection of humans and animals. The Paul-Ehrlich-Institut and the Friedrich-Loeffler-Institut are among the 14 partners involved and will support the project with its regulatory expertise as well as Biosafety Level 4 experimental capacity.
Crimean-Congo haemorrhagic fever is cause by the Crimean-Congo haemorrhagic virus (CCHFV). Ruminants constitute the primary viral reservoir. CCHFV is wide-spread and occurs in various countries in Europe, Asia, the Middle East, and Africa. The virus is transmitted by ticks and the close contact with infected blood or tissue.
Infected animals generally do not show any signs of disease, whereas patients develop flu-like symptoms with fever, muscle and limb ache, as well as neurological and gastrointestinal signs. A subset of those affected develop serious haemorrhagies, and the mortality rate lies around 30 percent. Up to now, neither effective antiviral treatments nor licensed vaccines are available.
The CCHFVaccine Project aims at stepping up efforts to develop and provide vaccines against CCHFV for humans and animals thereby using an One Health approach as already exemplified by the participation of both major German medical and veterinary infectious disease research institutes.
Vaccination of susceptible animals will be pursued to reduce the viral burden, whereas vaccine development for humans primarily aims at the protection of individuals at high risk for exposure. The project consortium is funded with six million € for a period of six years within the scope of the European research and innovation programme "Horizon 2020" (see below).
The CCHFVaccine Consortium is led by Professor Ali Mirazimi at the Swedish Health Agency, the Karolinska Institute, and the Swedish National Veterinary Institute. The Paul-Ehrlich-Institut, which is the competent authority for the authorisation of clinical trials, marketing authorisations, and official batch control in Germany, will provide expert advice in regulatory aspects.
The Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Island of Riems will assess the efficacies of newly developed animal vaccines by challenging cattle in the unique newly commissioned BSL4 high containment laboratory and animal facility. The third German partner involved is the Justus-Liebig University, which is specialised in vaccine design.
Horizon 2020 is the framework programme of the European Union for research and innovation. It promotes research, and as such, aims at developing a knowledge- and innovation-driven society and a competitive economy. At the same time it has the purpose of contributing to sustained development. In addition to the member states of the European Union, various other countries can participate in the Horizon 2020 program.
The Paul-Ehrlich-Institut, the Federal Institute for Vaccines and Biomedicines, in Langen near Frankfurt/Main is a senior federal authority reporting to the Federal Ministry of Health (Bundesministerium für Gesundheit, BMG). It is responsible for the research, assessment, and marketing authorisation of biomedicines for human use and immunological veterinary medicinal products. Its remit also includes the authorisation of clinical trials and pharmacovigilance, i.e. recording and evaluation of potential adverse effects.
Other duties of the institute include official batch control, scientific advice and inspections. In-house experimental research in the field of biomedicines and life science form an indispensable basis for the manifold tasks performed at the institute.
The Paul-Ehrlich-Institut, with its roughly 800 members of staff, also has advisory functions nationally (federal government, federal states (Länder)), and internationally (World Health Organisation, European Medicines Agency, European Commission, Council of Europe etc.).
http://fli.bund.de - FLI Friedrich-Loeffler-Institut
http://cordis.europa.eu/project/rcn/207211_en.html - CORDIS Project Information
https://www.uni-giessen.de/research/research-organizations/eu-projects/cooperati... - CCHFV-Projekt Info of Justus Liebig University Gießen
Dr. Susanne Stöcker | idw - Informationsdienst Wissenschaft
Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg
Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy