Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Edible Dormice: The older they get, the more they rejuvenate their cells

24.11.2016

The shortening of telomeres in cells was thought to be an important biomarker for lifespan and aging. The edible dormouse (Glis glis), a small hibernating rodent, now turns everything upside down. In contrast to humans and other animals, telomere length in the edible dormouse significantly increases in the second half of its life, as researchers from Vetmeduni Vienna found out just recently. The study was published in Scientific Reports.

“As far as I know, no previous study has reported such an effect of age on telomere lengthening,” says Franz Hoelzl, one of the authors. Apparently, this unique pattern is due to the peculiar life history of this species. They can reach maximum lifespan of 13 years, which is a Methuselah-like age for a small rodent.


Relative telomere length can be analysed using extracted DNA of collected buccal mucosa.

Vetmeduni Vienna

“This extreme lifespan is almost certainly related to their ability to rejuvenate telomeres”, says Hoelzl. Telomeres are the endcaps of chromosomes, which prevent, together with proteins, the degradation of coding DNA sequences.

Telomeres in small animals shorten fast, but in edible dormice they even grow

In normal somatic cells, telomeres are shortened with every cell division. Besides, oxidative stress has a strong effect on telomere erosion. However, the rate of telomere shortening differs between species. For instance, it has been shown before that telomeres in fast-aging, short-lived wild animals erode more rapidly than in slow-aging, long-lived species.

Earlier this year, the author Franz Hoelzl and his colleagues from Vetmeduni Vienna showed that edible dormice has the capability to re-elongated its telomeres, given that food availability is high. This finding raised the question about the long-term balance between telomere attrition and repair.

The relative telomere length (RTL) gave evidence

To find an answer, the team started a long-tem study on changes in telomere length. In the Vienna Woods in Austria they regularly checked 130 nest-boxes that are occupied by free-living dormice. The researchers collected the rodent’s buccal mucosa for three years. Thus, they could extract the DNA and determine the relative telomere length for each dormouse individually using qPCR. With this method scientists can define the amount of target DNA compared to a reference gene of the same sample.

Elongation does not only occur, it even increases in older edible dormice

“We found out that the telomeres were shortened in young animals but length significantly increased once the dormice were six years old or older. To top it all, the rate of telomere elongation also increased with increasing age of the dormice”, says Franz Hoelzl.

Among the variables tested, only age significantly affected RTL in a non-linear pattern with telomere length decreasing in younger and increasing in older dormice. Hoelz says, “Telomere length was not affected by time of the year, sex, body mass or reproductive activity at the time of sampling.”

Nevertheless, the analysis of long term reproduction-data of the same population shows that the probability to reproduce also increases with age. This finding could indicate that telomere elongation is actually part of the preparation for upcoming reproductive events, as gestation and lactation could increase oxidative stress and the animals may attempt to protect their genome.

Service:
The article "Telomeres are elongated in older individuals in a hibernating rodent, the edible dormouse (Glis glis)“ by Franz Hoelzl, Steve Smith, Jessica S. Cornils, Denise Aydinonat, Claudia Bieber and Thomas Ruf will be published embargoed in Scientific Reports (Nature Publishing Group) today, 24th of November. Embargo ends at 11:00am CET.

About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,300 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms. http://www.vetmeduni.ac.at

Scientific Contact:
Franz Hölzl
Research Institute of Wildlife Ecology
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-7273
franz.hoelzl@vetmeduni.ac.at

Released by:
Georg Mair
Science Communication / Corporate Communications
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-1165
georg.mair@vetmeduni.ac.at

Weitere Informationen:

http://www.vetmeduni.ac.at/en/infoservice/presseinformation/presseinformationen-...

Mag.rer.nat Georg Mair | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>