Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Dresden researchers manage transplantation of adrenal cells encapsulated in a bioreactor

17.02.2015

If the function of the adrenal gland is disturbed it does not produce enough stress-adjusting messengers. The results are serious and cause life-threatening diseases. Till now academic medicine provides only limited. Under the direction of Prof. Dr. Stefan R. Bornstein of the university hospital Carl Gustav Carus Dresden researchers developed an artificial adrenal system together with the medicine Nobel Prize Laureate Prof. Dr. Andrew Schally in an animal model. This makes future human transplantation of adrenal cells possible. Patients with adrenal failure, but also innate adrenal illnesses like the congenital adrenal syndrome will benefit from it.

If a person is under stress his body tips out stress regulators. These are Cortisol, Adrenalin and Noradrenalin - hormones and messenger substances - which intervene adjusting in the metabolism and help thus the organism to master the unusual load. Cortisol has an essential meaning for the coal hydrate household, the fat metabolism as well as the protein turnover.


Prof. Dr. med. Stefan R. Bornstein

Photo: University hospital Carl Gustav Carus Dresden

These hormones and messenger material are produced in the adrenal glands as central stress organs. By a sub-function of the adrenal gland, the so-called adrenal insufficiency, the production of the stress regulator decreases and the normal balance in the metabolism is disturbed. A state which has serious results for the health and can be even life-threatening.

Innate dysfuntion of hormone production clearly affectes the quality of life. An example is the so-called 21-hydroxylase deficiency, the most frequent form of the congenital syndrome there the adrenal glands produce excess androgens, which are male hormones.

The determining of the next step led to success: before the transplant the researchers gave the cells in a small capsule, an artificial adrenal system which they implanted-. The advantage: The artificial system ― developed by an Israeli enterprise ― makes an immunosuppression in the recipient superfluous. The capsule protects the donator's cells against attacks of the immune system but , passes the hormones by semi-permeable walls into the body of the receiver.

For Professor Bornstein an important step forward to the artificial adrenal system in humans has been taken: „Our vision is that people get even adrenal cells of another kind transplanted, as for example from pigs, in furture. The capsule creates the biotechnical condition for it, because it separates the donator's cells from the body of the receiver and transfers the hormones which are important for the metabolism exclusively"In the eyes of Dresden scientists this kind of transplantation will be suitable for patients with adrenal insufficiency but also with congenital diseases such as the lack of 21-hydroxylase.

The research findings from Dresden were now under the title "Transplantation of bovine adrenocortical cells encapsulated in alginate" in the prestigious journal Proceedings of the National Academy of Sciences, PNAS, published (doi:10.1073 / pnas.1500242112).

Contact
Universitätsklinikum Carl Gustav Carus Dresden
Technische Universität Dresden
Medizinische Klinik und Poliklinik III
Prof. Dr. med. Stefan R. Bornstein
Tel.: +49 0351 458 5955
Fax: +49 0351 458 6398
E-Mail: stefan.bornstein@uniklinkum-dresden.de

Weitere Informationen:

http://www.uniklinikum-dresden.de/mk3

Konrad Kästner | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>