If the function of the adrenal gland is disturbed it does not produce enough stress-adjusting messengers. The results are serious and cause life-threatening diseases. Till now academic medicine provides only limited. Under the direction of Prof. Dr. Stefan R. Bornstein of the university hospital Carl Gustav Carus Dresden researchers developed an artificial adrenal system together with the medicine Nobel Prize Laureate Prof. Dr. Andrew Schally in an animal model. This makes future human transplantation of adrenal cells possible. Patients with adrenal failure, but also innate adrenal illnesses like the congenital adrenal syndrome will benefit from it.
If a person is under stress his body tips out stress regulators. These are Cortisol, Adrenalin and Noradrenalin - hormones and messenger substances - which intervene adjusting in the metabolism and help thus the organism to master the unusual load. Cortisol has an essential meaning for the coal hydrate household, the fat metabolism as well as the protein turnover.
These hormones and messenger material are produced in the adrenal glands as central stress organs. By a sub-function of the adrenal gland, the so-called adrenal insufficiency, the production of the stress regulator decreases and the normal balance in the metabolism is disturbed. A state which has serious results for the health and can be even life-threatening.
Innate dysfuntion of hormone production clearly affectes the quality of life. An example is the so-called 21-hydroxylase deficiency, the most frequent form of the congenital syndrome there the adrenal glands produce excess androgens, which are male hormones.
The determining of the next step led to success: before the transplant the researchers gave the cells in a small capsule, an artificial adrenal system which they implanted-. The advantage: The artificial system ― developed by an Israeli enterprise ― makes an immunosuppression in the recipient superfluous. The capsule protects the donator's cells against attacks of the immune system but , passes the hormones by semi-permeable walls into the body of the receiver.
For Professor Bornstein an important step forward to the artificial adrenal system in humans has been taken: „Our vision is that people get even adrenal cells of another kind transplanted, as for example from pigs, in furture. The capsule creates the biotechnical condition for it, because it separates the donator's cells from the body of the receiver and transfers the hormones which are important for the metabolism exclusively"In the eyes of Dresden scientists this kind of transplantation will be suitable for patients with adrenal insufficiency but also with congenital diseases such as the lack of 21-hydroxylase.
The research findings from Dresden were now under the title "Transplantation of bovine adrenocortical cells encapsulated in alginate" in the prestigious journal Proceedings of the National Academy of Sciences, PNAS, published (doi:10.1073 / pnas.1500242112).
Universitätsklinikum Carl Gustav Carus Dresden
Technische Universität Dresden
Medizinische Klinik und Poliklinik III
Prof. Dr. med. Stefan R. Bornstein
Tel.: +49 0351 458 5955
Fax: +49 0351 458 6398
Konrad Kästner | idw - Informationsdienst Wissenschaft
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences