Stem cells persist in the adult mammalian brain and generate new neurons throughout life. A research group at the Biozentrum of the University of Basel reports in the current issue of "Science" that long-distance brain connections can target discrete pools of stem cells in their niche and stimulate them to divide and produce specific subtypes of olfactory bulb neurons. This allows the “on-demand” generation of particular types of neurons in the adult brain.
Our brain generates new neurons throughout life. A diversity of stimuli promotes stem cells in their niche to form neurons that migrate to their place of action. In an animal model Prof. Fiona Doetsch’s team at the Biozentrum of the University of Basel has now been able to show that feeding-related neurons in the hypothalamus, a brain control center for many physiological functions, stimulate a distinct type of stem cell to proliferate and mature into specific nerve cells in response to feeding.
Stem cells make neurons important for olfaction
Stem cells reside in only a few areas of the brain. The largest reservoir is the subventricular zone, where quiescent stem cells lie closely packed together. Signals from the environment can trigger stem cells to start dividing. The stem cells in the subventricular zone supply the olfactory bulb with neurons.
In rodents, almost 100,000 new neurons migrate from the stem cell niche to the olfactory bulb each day. Olfactory stimuli reaching the nose are processed in the olfactory bulb and the information is then sent to other brain regions. The closely interwoven network of diverse olfactory bulb neurons is important for distinguishing odors.
Stem cell activation over long distances
Each stem cell has its own identity, depending on its location in the subventricular zone. While new neurons are continuously generated, whether niche signals act to control different pools of stem cells is unknown.
“We have uncovered a novel long-distance and regionalized connection in the brain between the hypothalamus and the subventricular zone, and show that physiological states such as hunger and satiety can regulate the recruitment of specific pools of stem cells and in turn the formation of certain neuron subtypes in the olfactory bulb,” explains Doetsch.
When the animals fasted, the activity of the nerve cells in the hypothalamus decreased and with it also the rate of proliferation in the targeted stem cell population. This returns to normal levels when the animals feed again. The division of stem cells can be controlled by changing the activity of feeding-related neurons.
The researchers reported further that the targeted stem cell subpopulation gives rise to deep granule cells in the olfactory bulb, which may provide a substrate for adaptive responses to the environment. The results of the study raise the exciting possibility that neural circuits from diverse brain regions can regulate different pools of stem cells in response to various stimuli and states.
Alex Paul, Zayna Chaker and Fiona Doetsch
Hypothalamic regulation of distinct adult neural stem cells and neurogenesis
Science (2017), doi: 10.1126/science.aal3839
Prof. Dr. Fiona Doetsch, University of Basel, Biozentrum, Tel. +41 61 207 22 30, email: firstname.lastname@example.org
Dr. Katrin Bühler, University of Basel, Biozentrum, Kommunikation, Tel. +41 61 207 09 74, email: email@example.com
Olivia Poisson | Universität Basel
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy