Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery of a unique subcellular structure determining the orientation of cell division

12.08.2016

Cell division is a fundamental process of life, producing two cells from one single cell at each cell division. During animal development, a fertilized egg divides many times, increasing the number of cells, which are precisely organized within the animal's body.

How many times a cell undergoes cell division and how the two daughter cells are positioned after the division can be critical for shaping the animal. Although the machinery essential for cell division is well characterized and evolutionarily conserved, it remains unknown in most animals how a cell division can become oriented relative to the animal's body axis.


In the cell, the invaginations (white arrows) extend to the centrosome (blue/red dots).

Credit: NIBB

The work by Negishi et al., published recently in the electronic journal eLife, has revealed that in the sea squirt (Ciona intestinalis) embryo, the orientation of the cell division machinery in epithelial cells is controlled by a unique cell membrane structure, which we call an "invagination".

The first author, Dr. Takefumi Negishi, recalls "When I observed this structure dynamically moving and extending within the cell, I immediately thought this might be playing an essential role for cellular function."

Live imaging by fluorescence microscopy revealed that the invaginations originate from the posterior (tail) side of each epithelial cell and grows intracellularly toward the centrosome, an essential component of the cell division machinery. Using a specialized electron microscopy called "SBF-SEM", the authors demonstrated that the tip of invagination associates closely with the centrosome.

Furthermore, laser cutting of the invagination resulted in immediate recoil of both cut ends to opposite directions, highlighting that this polarized membrane structure is under tension.

Based on these findings, the authors propose an entirely new model for controlling cell division orientation, which involves the polarized membrane structure repositioning the cell division machinery to one end of the cell, thus orientating the subsequent cell division.

Professor Naoto Ueno, who co-supervised the current study, states "We hope our findings facilitates studies on similar membrane structures in other animals that might have diverse biological functions."

This study was conducted in collaboration between the National Institute for Basic Biology (Japan), the National Institute for Physiological Sciences (Japan) and The National Center for Scientific Research (France).

eLife
"Physical association between a novel plasma-membrane structure and centrosome orients cell division"
Takefumi Negishi, Naoyuki Miyazaki, Kazuyoshi Murata, Hitoyoshi Yasuo, Naoto Ueno
DOI: 10.7554/eLife.16550

Media Contact

NIBB PR Office
press@nibb.ac.jp

http://www.nins.jp/english/ 

NIBB PR Office | EurekAlert!

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>