Diabetics often have to contend with wounds that heal poorly. Researchers at the
Max Planck Institute for Biology of Ageing, the CMMC, the CECAD Excellence Cluster and the Institute of Genetics of the University of Cologne have now gained new insights into the underlying cellular mechanisms. Their findings could lead to the development of new treatment methods.
According to estimates by the International Diabetes Federation (IDF), some six million people in Germany suffer from diabetes mellitus, around 90 percent of whom have the type 2 form. The disease, which is triggered by a disturbance of insulin metabolism, has serious effects on the entire body. One problem these patients face is poor wound healing.
It had previously been assumed that high levels of glucose in the blood damages vessels and neurons and impairs the immune system, thereby accounting for the wound-healing problems. A Cologne-based research group headed by Linda Partridge, Director of the Max Planck Institute for Biology of Ageing, and Maria Leptin, professor at the Institute of Genetics of the University of Cologne, has now presented in a study that slowed insulin metabolism at the wound site directly affects neighbouring cells involved in wound healing.
Investigations of fly skin
Parisa Kakanj, the author of the study, examined the skin of larvae of the fruit fly Drosophila melanogaster. These flies serve as models for diabetes, because insulin metabolism has been strongly conserved over the course of evolution, meaning that flies and mammals are very similar in this respect. Using a precision laser, Kakanj removed a cell from the outermost skin layer of fruit fly larvae and then observed what happens in the neighbouring cells live under the microscope.
“Immediately after a skin injury, the neighbouring cells respond by forming an actomyosin cable,” Kakanj explains. The cable consists of proteins that otherwise occur in muscle fibres, where they are responsible for muscular contraction. After an injury, the cable forms a contractile ring around the wound. It then contracts, sealing off the gap caused by the wound. “However, if insulin metabolism is impaired, as in our genetically modified flies, the cable is weaker and forms much later. This results in incomplete or slow wound healing,” as Kakanj relates.
Local treatment for better wound healing
New treatments for impaired wound healing could precisely target this mechanism. “Our findings raise hope of a potential treatment for diabetics. In future, it may be possible to treat wound sites with drugs that locally activate insulin metabolism,” Kakanj explains. The research team is now working closely with Sabine Eming, a senior dermatologist at the clinic and polyclinic for dermatology and venereology at the University Hospital Cologne, the CMMC and the Excellence Cluster for Ageing Research at the University of Cologne in order to investigate ways to implement this approach.
Dr. Maren Berghoff | Max-Planck-Institut für Biologie des Alterns
Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie
Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
21.04.2017 | Physics and Astronomy
21.04.2017 | Health and Medicine
21.04.2017 | Physics and Astronomy