Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Constructing complex molecules with atomic precision

02.06.2015

Researchers in Russia have developed a waste-free and cost-effective approach for preparing complex organic molecules and revealing the physical nature of the processes that control the direction of chemical transformations.

 Increasing demand from high technology sectors for better approaches to industrial production is prompting the emergence of a new generation of chemical synthesis methods.


Copyright : Dr. E.G.Gordeev, Ananikov Laboratory, Moscow

“Until recently, it was not possible to construct complex organic molecules by manipulating individual atoms,” says Professor Valentine Ananikov, laboratory head of the Zelinsky Institute of Organic Chemistry at the Russian Academy of Sciences.

“But the development of new lab equipment and state-of-the-art organic synthesis methods are facilitating a new direction in chemistry: the preparation of organic molecules, biologically active compounds, pharmaceutical substances and smart materials with atomic precision.”

Traditional methods for the preparation of organic molecules require complicated technologies, the use of expensive catalysts and the application of toxic reagents.

Now, scientists from 14 different laboratories representing leading research centres in Russia are combining their expertise to develop safer and more costefficient procedures for chemical production.

Their strategy includes the replacement of expensive catalysts (such as palladium, platinum and rhodium) with easier to obtain and cheaper analogues (e.g. nickel, copper and manganese). The new approach also avoids the use of toxic reagents and the production of wastes by applying alternative procedures based on sustainable protocols.

Described in Russian Chemical Reviews, the team’s approach involves preparing a target molecule by connecting molecular fragments to each other with atomic precision and carrying out all chemical modifications with complete selectivity. So far, Professor Ananikov and his colleagues have applied the new approach to synthesise some 300 individual molecules – ranging from flame retardants and ligands for catalysis to biologically active compounds and pharmaceutical building blocks.

Among its achievements, the multidisciplinary team has shed new light on the factors responsible for the formation of chemical bonds between particular atoms or molecular fragments, while completely controlling the selectivity of these reactions. What’s more, in depth studies carried out in the 14 laboratories have resulted in efficient protocols for improving the performance of chemical transformations. They have also contributed to the development of a new generation of industrial procedures.

According to the Russian team, the new approach could also be used in connection with many established procedures for preparing organic molecules such as cross-coupling reactions, fluorination reactions, catalytic hydrogenations and oxidations, among others. The researchers are now focused on implementing atomic precision chemical reactions on an industrial scale and fostering international collaborations.

For further information contact:
Professor Valentine Ananikov
Zelinsky Institute of Organic Chemistry
Russian Academy of Sciences
E-mail: val@ioc.ac.ru

*This article also appears in Asia Research News 2015 (P.58).

Associated links
Read Asia Research News 2015
Download a copy of Asia Research News 2015 for free

Ananikov Laboratory | ResearchSEA

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>