Biophysical Research for Future Implants
With society growing older, implants are often necessary to preserve mobility and health-related quality of life. However, by far not all implantations are successful, and often lengthy and risky after-treatments are necessary, for example because the implant is not well integrated into bone.
PhD student Judith Hohmann, photo: Th. Jung
In order to make implants more reliable, their surface is roughened, so that the cells of the surrounding bone tissue grow faster into the surface. The cellular mechanisms of this growth enhancement are not yet known.
In a recently published study Professor Georg von Freymann and his PhD student Judith Hohmann, for the first time systematically showed the connections between three-dimensional surface structure and cell growth.
"If we understand how cells behave on differently structured surfaces, this could eventually lead to improved implants," the young biophysicist Hohmann explains the motivation for the research project. The work was carried out at the Physics Department of the University of Kaiserslautern within the framework of the State Research Center OPTIMAS.
To better understand the interaction of the cells, various structures were fabricated with feature sizes of a few microns. For this, Hohmann made use of 3D micro-printing that builds three-dimensional polymer structures from a liquid starting material.
The structures were then coated with titanium dioxide so that they are chemically identical to the surfaces of implants. On these structures, the young scientist let then cells grow that are very similar to those of bone tissue. Cell growth was then compared to that on unstructured surfaces.
The structures resembled micro climbing frames and were also used as such by the cells. Along the scaffolds the cells grew much faster than in the control experiments without structured surfaces for adhesion contact.
The cells had a distinct preference for certain shapes and distances of different scaffolds: A change in the spacing of posts of the climbing frame-like structures had significant influence on the growth of cells. Also the cell morphology strongly depends on their structural environment. The studies provided a first approach to better understand the growth behavior of the cells on the artificial material. Fortunately, the functionality of the cells was not affected, they still behave like bone tissue.
The results of this study may in future lead to improved implants that are overgrown quicker by the surrounding bone tissue. Von Freymann and Hohmann published their results in the internationally renowned journal Advanced Functional Materials. The editor of the journal even selected their study for the cover of the print edition.
For further information:
Influence of Direct Laser Written 3D Topographies on Proliferation and Differentiation of Osteoblast-Like Cells: Towards Improved Implant Surfaces
Judith K. Hohmann and Georg von Freymann
Advanced Functional Materials 24, 6573–6580 (2014); DOI: 10.1002/adfm.201401390
Prof. Dr. Georg von Freymann, TU Kaiserslautern
(Phone +49 631 205 5225; email@example.com)
Thomas Jung | Technische Universität Kaiserslautern
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy