Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Climbing Frames for Cells Influence Growth and Morphology

12.11.2014

Biophysical Research for Future Implants

With society growing older, implants are often necessary to preserve mobility and health-related quality of life. However, by far not all implantations are successful, and often lengthy and risky after-treatments are necessary, for example because the implant is not well integrated into bone.


PhD student Judith Hohmann, photo: Th. Jung

In order to make implants more reliable, their surface is roughened, so that the cells of the surrounding bone tissue grow faster into the surface. The cellular mechanisms of this growth enhancement are not yet known.

In a recently published study Professor Georg von Freymann and his PhD student Judith Hohmann, for the first time systematically showed the connections between three-dimensional surface structure and cell growth.

"If we understand how cells behave on differently structured surfaces, this could eventually lead to improved implants," the young biophysicist Hohmann explains the motivation for the research project. The work was carried out at the Physics Department of the University of Kaiserslautern within the framework of the State Research Center OPTIMAS.

To better understand the interaction of the cells, various structures were fabricated with feature sizes of a few microns. For this, Hohmann made use of 3D micro-printing that builds three-dimensional polymer structures from a liquid starting material.

The structures were then coated with titanium dioxide so that they are chemically identical to the surfaces of implants. On these structures, the young scientist let then cells grow that are very similar to those of bone tissue. Cell growth was then compared to that on unstructured surfaces.

The structures resembled micro climbing frames and were also used as such by the cells. Along the scaffolds the cells grew much faster than in the control experiments without structured surfaces for adhesion contact.

The cells had a distinct preference for certain shapes and distances of different scaffolds: A change in the spacing of posts of the climbing frame-like structures had significant influence on the growth of cells. Also the cell morphology strongly depends on their structural environment. The studies provided a first approach to better understand the growth behavior of the cells on the artificial material. Fortunately, the functionality of the cells was not affected, they still behave like bone tissue.

The results of this study may in future lead to improved implants that are overgrown quicker by the surrounding bone tissue. Von Freymann and Hohmann published their results in the internationally renowned journal Advanced Functional Materials. The editor of the journal even selected their study for the cover of the print edition.

For further information:
Influence of Direct Laser Written 3D Topographies on Proliferation and Differentiation of Osteoblast-Like Cells: Towards Improved Implant Surfaces
Judith K. Hohmann and Georg von Freymann
Advanced Functional Materials 24, 6573–6580 (2014); DOI: 10.1002/adfm.201401390

Contact:
Prof. Dr. Georg von Freymann, TU Kaiserslautern
(Phone +49 631 205 5225; georg.freymann@physik.uni-kl.de)


Weitere Informationen:

http://www.uni-kl.de

Thomas Jung | Technische Universität Kaiserslautern

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>