Study explains the link between cilia and diabetes
Tiny extensions on cells, cilia, play an important role in insulin release, according to a new study, which is published in Nature Communications. The researchers report that the cilia of beta cells in the pancreas are covered with insulin receptors and that changed ciliary function can be associated with the development of type 2 diabetes.
Cilia are tiny extensions on cells and they are credited with many important functions, including transduction of signals in cells. Defects in cilia have been implied in several diseases and pathological conditions. Thus, scientists at Karolinska Institutet in Stockholm, University College London and the Helmholtz Zentrum München (HMGU) took interest in the role of cilia in blood glucose regulation and type 2-diabetes.
"It has been known for some time that the rate of type 2 diabetes is above average in people with ciliopathy, which is a pathological ciliary dysfunction", says Jantje Gerdes, previously at Karolinska Institutet and now at the Institute of Diabetes and Regeneration Research at the HMGU, first author of the study. "Our results confirm this observation and additionally explain how cilia are linked to glucose metabolism and diabetes."
The researchers investigated the function of ciliary cell extensions in the insulin-secreting pancreatic beta cells. Insulin is the hormone that reduces blood glucose levels. When the investigators stimulated the beta cells with glucose the number of insulin receptors on their cilia increased. When circulating insulin binds to the receptors it stimulates the release of more insulin into the blood. The cilia consequently play an important role in the release and signal transduction of insulin.
The investigators also studied what happens when the cilia are defective. They found that in mice with few or defective cilia the insulin release was reduced and the animals had significantly elevated blood glucose levels.
"Ciliary dysfunction and defective glucose utilization are directly linked", says Per-Olof Berggren at the Rolf Luft Research Center for Diabetes and Endocrinology at Karolinska Institutet, principal investigator of the study. "Ciliopathies therefore have a potential function as models in the investigation of many still unknown mechanisms that underlie diabetes."
The research was supported by, among others, grants from the Swedish Research Council, the Novo Nordisk Foundation, the European Research Council, The Family Erling-Persson Foundation, the Knut and Alice Wallenberg Foundation, and the Stichting af Jochnick Foundation.
Publication: 'Ciliary dysfunction impairs pancreatic insulin secretion and promotes development of type 2 diabetes in rodents', Jantje M. Gerdes, Sonia Christou-Savina, Yan Xiong, Tilo Moede, Noah Moruzzi, Patrick Karlsson-Edlund, Barbara Leibiger, Ingo B. Leibiger, Claes-Göran Östenson, Philip L. Beales, and Per-Olof Berggren, Nature Communications, online 6 November 2014, doi: 10.1038/ncomms6308.
Contact the Press Office: ki.se/pressroom
Karolinska Institutet - a medical university: ki.se/english
Press Office | EurekAlert!
Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo
Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Life Sciences
23.05.2018 | Physics and Astronomy
23.05.2018 | Life Sciences