Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cellular extensions with a large effect

06.11.2014

Study explains the link between cilia and diabetes

Tiny extensions on cells, cilia, play an important role in insulin release, according to a new study, which is published in Nature Communications. The researchers report that the cilia of beta cells in the pancreas are covered with insulin receptors and that changed ciliary function can be associated with the development of type 2 diabetes.

Cilia are tiny extensions on cells and they are credited with many important functions, including transduction of signals in cells. Defects in cilia have been implied in several diseases and pathological conditions. Thus, scientists at Karolinska Institutet in Stockholm, University College London and the Helmholtz Zentrum München (HMGU) took interest in the role of cilia in blood glucose regulation and type 2-diabetes.

"It has been known for some time that the rate of type 2 diabetes is above average in people with ciliopathy, which is a pathological ciliary dysfunction", says Jantje Gerdes, previously at Karolinska Institutet and now at the Institute of Diabetes and Regeneration Research at the HMGU, first author of the study. "Our results confirm this observation and additionally explain how cilia are linked to glucose metabolism and diabetes."

The researchers investigated the function of ciliary cell extensions in the insulin-secreting pancreatic beta cells. Insulin is the hormone that reduces blood glucose levels. When the investigators stimulated the beta cells with glucose the number of insulin receptors on their cilia increased. When circulating insulin binds to the receptors it stimulates the release of more insulin into the blood. The cilia consequently play an important role in the release and signal transduction of insulin.

The investigators also studied what happens when the cilia are defective. They found that in mice with few or defective cilia the insulin release was reduced and the animals had significantly elevated blood glucose levels.

"Ciliary dysfunction and defective glucose utilization are directly linked", says Per-Olof Berggren at the Rolf Luft Research Center for Diabetes and Endocrinology at Karolinska Institutet, principal investigator of the study. "Ciliopathies therefore have a potential function as models in the investigation of many still unknown mechanisms that underlie diabetes."

The research was supported by, among others, grants from the Swedish Research Council, the Novo Nordisk Foundation, the European Research Council, The Family Erling-Persson Foundation, the Knut and Alice Wallenberg Foundation, and the Stichting af Jochnick Foundation.

Publication: 'Ciliary dysfunction impairs pancreatic insulin secretion and promotes development of type 2 diabetes in rodents', Jantje M. Gerdes, Sonia Christou-Savina, Yan Xiong, Tilo Moede, Noah Moruzzi, Patrick Karlsson-Edlund, Barbara Leibiger, Ingo B. Leibiger, Claes-Göran Östenson, Philip L. Beales, and Per-Olof Berggren, Nature Communications, online 6 November 2014, doi: 10.1038/ncomms6308.

Contact the Press Office: ki.se/pressroom

Karolinska Institutet - a medical university: ki.se/english

Press Office | EurekAlert!

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>