Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An injectable guidance system for nerve cells

05.04.2017

In many tissues of the human body, such as nerve tissue, the spatial organization of cells plays an important role. Nerve cells and their long protrusions assemble into nerve tracts and transport information throughout the body. When such a tissue is injured, an accurate spatial orientation of the cells facilitates the healing process. Scientists from the DWI – Leibniz Institute for Interactive Materials in Aachen developed an injectable gel, which can act as a guidance system for nerve cells. They recently published their results obtained from cell culture experiments in the journal ‚Nano Letters‘.

Inside the body, an extracellular matrix surrounds the cells. It provides mechanical support and promotes spatial tissue organization. In order to regenerate damaged tissue, an artificial matrix can temporally replace the natural extracellular matrix.


Dr.-Ing. Laura De Laporte and PhD student Jonas Rose analyze the orientation of nerve cells (red) along the paths provided by gel rods (green).

J. Hillmer, DWI

This matrix needs to mimic the natural cell environment in order to efficiently stimulate the regenerative potential of the surrounding tissue. Solid implants, however, may impair remaining healthy tissue whereas soft, injectable materials allow for a minimal invasive therapy, which is particularly beneficial for sensitive tissues, such as the spinal cord. Unfortunately, up to now, artificial soft materials did not yet reproduce the complex structures and spatial properties of natural tissues.

A team of scientists, headed by Dr.-Ing. Laura De Laporte from the DWI – Leibniz Institute for Interactive Materials, developed a new, minimal invasive material termed ‚Anisogel‘. “If you aim to enhance the regeneration of damaged spinal cord tissue, you need to come up with a new material concept,” says Jonas Rose. He is a PhD student working on the Anisogel project.

“We use micrometer-sized building blocks and assemble them into 3D hierarchically organized structures.” Anisogel consists of two gel components. Many, microscopically small, soft rod-shaped gels, incorporated with a low amount of magnetic nanoparticles, are the first component. Using a weak magnetic field, scientists can orient the gel rods, after which a very soft surrounding gel matrix is crosslinked, forming the structural guidance system.

The gel rods, being stabilized by the gel matrix, maintain their orientation, even after removal of the magnetic field. Using cell culture experiments, the researchers demonstrate that cells can easily migrate through this gel matrix, and that nerve cells and fibroblasts orient along the paths provided by this guidance system.

A low amount of one percent gel rods inside the entire Anisogel volume is proven to be sufficient to induce linear nerve growth. The material, developed by the Aachen-based scientists, is the first injectable biomaterial, which assembles into a controlled oriented structure after injection and provides a functional guidance system for cells.

„To meet the complex requirements of this approach, the project team includes researchers with very different areas of expertise,“ says Laura De Laporte, whose research is supported by a Starting Grant of the European Research Council. „This interdisciplinary work is what makes this project so fascinating.“

„Although our cell culture experiments were successful, we are prepared to go a long way to translate our Anisogel into a medical therapy. In collaboration with the Uniklinik RWTH Aachen, we currently plan pre-clinical studies to further test and optimize this material.“

With its work on bioactive materials, the DWI – Leibniz Institute for Interactive Materials contributes to the research network ‚Leibniz Health Technologies’. Within this network, 14 institutes of the Leibniz Association work on specific technical solutions for urgent medical problems. The network’s overall motivation is to improve medical treatment of patients. Its interdisciplinary approach aims to coalesce prevention, diagnostics and therapy, thereby increasing the health-related quality of life.

Publication:
Rose, J. C., Cámara-Torres, M., Rahimi, K., Köhler, J., Möller, M., & De Laporte, L. (2017). Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance. Nano Letters.

Dr. Janine Hillmer | idw - Informationsdienst Wissenschaft
Further information:
http://www.dwi.rwth-aachen.de

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>