Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Alcohol abuse linked to newly identified gene network

02.12.2014

Researchers at The University of Texas at Austin have identified a network of genes that appear to work together in determining alcohol dependence. The findings, which could lead to future treatments and therapies for alcoholics and possibly help doctors screen for alcoholism, are being published this week in the journal Molecular Psychiatry.

By comparing patterns of genetic code from the brain tissue of alcoholics and nonalcoholics, the researchers discovered a particular set of genes co-expressed together in the individuals who had consumed the most alcohol. Specifically, certain sets of genes were strongly linked as networks in alcoholics, but not in nonalcoholics.

"This provides the most comprehensive picture to date of the gene sets that drive alcohol dependence," said R. Adron Harris, director of The University of Texas at Austin's Waggoner Center for Alcohol and Addiction Research. "We now have a much clearer picture of where specific traits related to alcohol dependence overlap with specific expressions in genetic code."

Scientists have known for some time that genetics play a role in alcoholism and addiction and that the tendency for dependence to be genetically linked is more complicated than the presence or absence of any one gene. The new research, however, represents the first time scientists used revolutionary bioinformatics technology of RNA sequencing to identify the specific group of different genes that, expressed together, are highly correlated with alcohol dependence.

"We hope our model can serve as a type of Wikipedia of alcohol dependence, helping to break down the complexities of alcohol dependence and becoming a reference for future research into drug therapies," said Sean Farris, a postdoctoral fellow also at the Waggoner Center and lead author of the study.

Only three drugs have approval from the Food and Drug Administration to treat alcoholism, and none offers a silver bullet in helping people dependent on alcohol end their addiction. The identification of genetic factors and networks in the brains of alcoholics gives drug researchers more information to work from and may one day allow for better screenings to evaluate a person's risk factors for alcohol dependence, possibly even before the onset of heavy drinking.

###

Authors of the study in addition to Farris are lead research scientist R. Dayne Mayfield of the Waggoner Center; bioinformatician Dhivya Arasappan of the Center for Systems and Synthetic Biology; Scott Hunicke-Smith, director of the Genomic Sequencing and Analysis Facility; and Harris, director of the Waggoner Center. All are from the university's College of Natural Sciences.

Support for the research came from the National Institute on Alcohol Abuse and Alcoholism, with funding through the American Recovery and Reinvestment Act of 2009.

Christine Sinatra | EurekAlert!
Further information:
http://www.utexas.edu/

More articles from Life Sciences:

nachricht Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>