Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Alcohol abuse linked to newly identified gene network


Researchers at The University of Texas at Austin have identified a network of genes that appear to work together in determining alcohol dependence. The findings, which could lead to future treatments and therapies for alcoholics and possibly help doctors screen for alcoholism, are being published this week in the journal Molecular Psychiatry.

By comparing patterns of genetic code from the brain tissue of alcoholics and nonalcoholics, the researchers discovered a particular set of genes co-expressed together in the individuals who had consumed the most alcohol. Specifically, certain sets of genes were strongly linked as networks in alcoholics, but not in nonalcoholics.

"This provides the most comprehensive picture to date of the gene sets that drive alcohol dependence," said R. Adron Harris, director of The University of Texas at Austin's Waggoner Center for Alcohol and Addiction Research. "We now have a much clearer picture of where specific traits related to alcohol dependence overlap with specific expressions in genetic code."

Scientists have known for some time that genetics play a role in alcoholism and addiction and that the tendency for dependence to be genetically linked is more complicated than the presence or absence of any one gene. The new research, however, represents the first time scientists used revolutionary bioinformatics technology of RNA sequencing to identify the specific group of different genes that, expressed together, are highly correlated with alcohol dependence.

"We hope our model can serve as a type of Wikipedia of alcohol dependence, helping to break down the complexities of alcohol dependence and becoming a reference for future research into drug therapies," said Sean Farris, a postdoctoral fellow also at the Waggoner Center and lead author of the study.

Only three drugs have approval from the Food and Drug Administration to treat alcoholism, and none offers a silver bullet in helping people dependent on alcohol end their addiction. The identification of genetic factors and networks in the brains of alcoholics gives drug researchers more information to work from and may one day allow for better screenings to evaluate a person's risk factors for alcohol dependence, possibly even before the onset of heavy drinking.


Authors of the study in addition to Farris are lead research scientist R. Dayne Mayfield of the Waggoner Center; bioinformatician Dhivya Arasappan of the Center for Systems and Synthetic Biology; Scott Hunicke-Smith, director of the Genomic Sequencing and Analysis Facility; and Harris, director of the Waggoner Center. All are from the university's College of Natural Sciences.

Support for the research came from the National Institute on Alcohol Abuse and Alcoholism, with funding through the American Recovery and Reinvestment Act of 2009.

Christine Sinatra | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
23.03.2018 | Physikalisch-Technische Bundesanstalt (PTB)

nachricht North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>