Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A twisted world -- chemists build a molecular banister

13.11.2014

Chemists at the University of Basel in Switzerland have succeeded in twisting a molecule by combining molecular strands of differing lengths. The longer strand winds around a central axis like a staircase banister, creating a helical structure that exhibits special physical properties. The results were published in the renowned scientific journal Angewandte Chemie International Edition.

The chemistry of all substances is to a large extent defined by their spatial arrangement. Many molecules can be present in two forms (enantiomers), which behave like a person's right and left hand.


Based on the strands of different lengths (blue and gray), the new helical molecule (right) adopts a spatial arrangement (schematic diagram in the center) that resembles the banister of a spiral staircase (left).

Credit: (Fig: University of Basel, Department of Chemistry)

In particular, the organism makes a highly specific distinction between left- and right-handed molecules - a substance can, for example, be extremely active as a drug in one form, while its mirror image is entirely inert. The fundamental understanding of this "chirality", as it is called, has long been a central component of research in the field of chemistry.

Connecting strands of different sizes

The researchers headed by Professor Marcel Mayor in the Department of Chemistry at the University of Basel have developed a new approach to contort a small molecule into a form similar in appearance to the banister on a spiral staircase.

At the molecular level, the interlinking of two oligomer strands with different lengths forces to the longer strand to wind around the shorter on its own to balance out the discrepancy in length. This creates a helix with a uniform twisting direction. As a consequence the entire molecule becomes chiral.

The researchers were also able to demonstrate that it is possible to dynamically change the form of the helical molecule from left-handed to right and back again in just a few hours.

"It is not just the structural elegance of this molecule which makes it so unique," says Mayor. "Above all, it is a completely new way of constructing a continuous helix."

Efficient procedures for creating chiral compounds generate much interest in basic research and the industrial sector - they can, for example, be used in biological systems research, crop protection chemistry, and the pharmaceutical and fragrance industries. The project was financially supported by the Swiss National Science Foundation.

Original source

Rickhaus, M., Bannwart, L. M., Neuburger, M., Gsellinger, H., Zimmermann, K., Häussinger, D. and Mayor, M.
Inducing Axial Chirality in a "Geländer" Oligomer by Length Mismatch of the Oligomer Strands
Angewandte Chemie International Edition (2014) | doi: 10.1002/anie.201408424

Olivia Poisson | EurekAlert!
Further information:
http://www.unibas.ch

More articles from Life Sciences:

nachricht What the world's tiniest 'monster truck' reveals
23.08.2017 | American Chemical Society

nachricht Treating arthritis with algae
23.08.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>