Chemists at the University of Basel in Switzerland have succeeded in twisting a molecule by combining molecular strands of differing lengths. The longer strand winds around a central axis like a staircase banister, creating a helical structure that exhibits special physical properties. The results were published in the renowned scientific journal Angewandte Chemie International Edition.
The chemistry of all substances is to a large extent defined by their spatial arrangement. Many molecules can be present in two forms (enantiomers), which behave like a person's right and left hand.
In particular, the organism makes a highly specific distinction between left- and right-handed molecules - a substance can, for example, be extremely active as a drug in one form, while its mirror image is entirely inert. The fundamental understanding of this "chirality", as it is called, has long been a central component of research in the field of chemistry.
Connecting strands of different sizes
The researchers headed by Professor Marcel Mayor in the Department of Chemistry at the University of Basel have developed a new approach to contort a small molecule into a form similar in appearance to the banister on a spiral staircase.
At the molecular level, the interlinking of two oligomer strands with different lengths forces to the longer strand to wind around the shorter on its own to balance out the discrepancy in length. This creates a helix with a uniform twisting direction. As a consequence the entire molecule becomes chiral.
The researchers were also able to demonstrate that it is possible to dynamically change the form of the helical molecule from left-handed to right and back again in just a few hours.
"It is not just the structural elegance of this molecule which makes it so unique," says Mayor. "Above all, it is a completely new way of constructing a continuous helix."
Efficient procedures for creating chiral compounds generate much interest in basic research and the industrial sector - they can, for example, be used in biological systems research, crop protection chemistry, and the pharmaceutical and fragrance industries. The project was financially supported by the Swiss National Science Foundation.
Rickhaus, M., Bannwart, L. M., Neuburger, M., Gsellinger, H., Zimmermann, K., Häussinger, D. and Mayor, M.
Inducing Axial Chirality in a "Geländer" Oligomer by Length Mismatch of the Oligomer Strands
Angewandte Chemie International Edition (2014) | doi: 10.1002/anie.201408424
Olivia Poisson | EurekAlert!
Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
23.03.2018 | Physikalisch-Technische Bundesanstalt (PTB)
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
23.03.2018 | Event News
19.03.2018 | Event News
16.03.2018 | Event News
23.03.2018 | Life Sciences
23.03.2018 | Materials Sciences
23.03.2018 | Process Engineering