A biochemical compound developed as a radioactive tracer for cell proliferation shows increasing potential for use in cancer imaging, according to a recent paper published in the Pertanika Journal of Science & Technology.
In the paper, an international team reviewed studies conducted over the past 30 years on a particular tracer, called “18F-FLT,” and found that it has the potential to improve diagnostic imaging, and thus treatment, of some cancers.
Copyright : lightwise via 123rf
One way that tumours are diagnosed is by using a radioisotope-labelled tracer that is injected into the body and taken up by cancer cells. Those areas are then highlighted in positron emission tomography (PET) scans.
The biomarker most often used for these scans is a radioactive glucose compound: (18F) fluoro-2-deoxy-D-glucose (18F-FDG). However, this tracer can produce false positives when taken up by normal cells, or false negatives when not enough is taken up to capture the true extent of a cancer.
Another, newer biomarker, (18F)-3’-fluoro-3’-deoxythymidine (18F-FLT), shows promise for specifically targeting proliferating cells. Several studies have found it is less likely to be taken up by inflamed tissue or benign cancer cells, thereby improving the accuracy of cancer diagnostics.
“It is well accepted that 18F-FDG is the ubiquitous marker in PET oncological practice. Nevertheless, 18F-FLT is an exciting marker with improved specificity that could be the number one candidate for therapeutic monitoring,” wrote the lead author, Hassan Hishar, of the Universiti Putra Malaysia.
The 18F-FLT tracer combines a sugar and thymine, one of the four main components of DNA. The compound is incorporated into DNA when a particular gene (TK1) is active, and that gene is much more active in malignant tumours.
18F-FLT has proved better than the more common biomarker, 18F-FDG, in revealing a variety of cancers, including bone marrow, pancreatic and lung cancer. However, it is unclear how well it works for breast and brain cancer, and studies have found it is less effective at detecting colorectal and melanoma cancer.
The team recommends further research to better understand the potential of 18F-FLT in cancer imaging.
For more information about each research, please contact:
Centre for Diagnostic Nuclear Imaging,
Universiti Putra Malaysia
43400 Serdang, Selangor, Malaysia
Tel: +(603) 8947 1641; Mobile: +(6012) 270 7486.
About Pertanika Journal of Science & Technology (JST)
Pertanika Journal of Science & Technology (JST) is published by Universiti Putra Malaysia in English and is open to authors around the world regardless of nationality. Currently, it is published twice a year in January and July. Other Pertanika series include Pertanika Journal of Tropical Agricultural Science (JTAS), and Pertanika Journal of Social Sciences & Humanities (JSSH).
Pertanika Journal of Science & Technology aims to provide a forum for high quality research related to science and engineering research. Areas relevant to the scope of the journal include: bioinformatics, bioscience, biotechnology and bio-molecular sciences, chemistry, computer science, ecology, engineering, engineering design, environmental control and management, mathematics and statistics, medicine and health sciences, nanotechnology, physics, safety and emergency management, and related fields of study.
The paper is available from this link:
For more information about the journal, contact:
The Chief Executive Editor (UPM Journals)
Head, Journal Division, UPM Press
Office of the Deputy Vice Chancellor (R&I)
IDEA Tower 2, UPM-MDTC Technology Centre
Universiti Putra Malaysia
43400 Serdang, Selangor
Phone: +(603) 8947 1622 | +(6016) 217 4050
Date of Release: 29 January 2016.
The Chief Executive Editor, UPM Journals
Dr Nayan KANWAL, FRSA, ABIM, AMIS, Ph.D. | Research SEA
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research