Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A Map of the Cell’s Power Station

18.08.2017

Researchers from the University of Freiburg are mapping the distribution of all proteins in mitochondria for the first time

Mitochondria are the cell's power stations; they transform the energy stored in nutrients so that cells can use it. If this function is disturbed, many different diseases can develop that often affect organs with a high metabolism, like the brain or the heart.


The net-like structure of green colored mitochondria from the baker's yeast model organism.

Source: AG Meisinger

The research labs at the University of Freiburg led by Prof. Dr. Chris Meisinger and Dr. Nora Vögtle from the Institute of Biochemistry and Molecularbiology have collaborated with scientists from the Leibniz Institute for Analytical Sciences (ISAS) in Dortmund to successfully map the landscape of proteins in the different reaction chambers, or subcompartments, of mitochondria for the first time. They presented their research in the scientific journal Nature Communications.

Mitochondria consist of four subcompartments: one outer and one inner membrane, which are each surrounded by watery compartments, the intermembrane space, and the so-called matrix, which is the innermost reaction chamber of mitochondria. Each of these subcompartments has its own protein equipment to carry out specific functions.

In addition to providing energy, mitochondria do other important metabolic tasks that involve proteins, like controlling the programmed death of cells. There are roughly 1,500 different species of these proteins in humans, while baker's yeast, which the scientists used as a model, has 1,000. Until now, researchers were unable to attribute many of these proteins to one of the four subcompartments. This is important in order to understand the exact mechanism of many metabolic pathways as well as new functions of previously unknown proteins.

Using isolated mitochondria from baker's yeast, the groups of researchers were able to apply various fractionation methods to meticulously isolate the proteins in each compartment and hence successfully map virtually the entire protein landscape of mitochondria.

In their research, the scientists from the University of Freiburg were also able to discover more than 200 additional proteins that had previously not been attributed to mitochondria. Their published study could thus serve the international research community as a basis for studying the potential new functions of mitochondria and for better understanding not only the central biochemical processes in cells, but also the development of many diseases.

Chris Meisinger is a professor at the Institute of Biochemistry and Molecular Biology at the University of Freiburg and is a member of the University of Freiburg's excellence cluster BIOSS Centre for Biological Signalling Studies. Nora Vögtle is the head of an independent junior research group funded under the Emmy Noether program of the German Research Council (DFG) at the Institute of Biochemistry and Molecular Biology.

Original Publication:
Vögtle, F.N., Burkhart, J.M., Gonczarowska-Jorge, H., Kücükköse, C., Taskin, A.A., Kopczynski, D., Ahrends, R., Mossmann, D., Sickmann, A., Zahedi, R.P. and Meisinger, C. (2017). Landscape of submitochondrial protein distribution. Nature Communications. DOI: 10. 1038/s41467-017-00359-0

Contact:
Prof. Dr. Chris Meisinger
Institute of Biochemistry and Molecular Biology
University of Freiburg
Phone: +49 (0)761 / 203 - 5287
E-Mail: chris.meisinger@biochemie.uni-freiburg.de

Dr. Nora Vögtle
Institute of Biochemistry and Molecular Biology
University of Freiburg
Phone: 49 (0)761 / 203 -97474
E-Mail: nora.voegtle@biochemie.uni-freiburg.de

Weitere Informationen:

https://www.pr.uni-freiburg.de/pm-en/2017/a-map-of-the-cells-power-station

Rudolf-Werner Dreier | idw - Informationsdienst Wissenschaft

Further reports about: Biology Molecular Biology metabolic mitochondria proteins

More articles from Life Sciences:

nachricht Rochester scientists discover gene controlling genetic recombination rates
23.04.2018 | University of Rochester

nachricht One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Structured light and nanomaterials open new ways to tailor light at the nanoscale

23.04.2018 | Physics and Astronomy

On the shape of the 'petal' for the dissipation curve

23.04.2018 | Physics and Astronomy

Clean and Efficient – Fraunhofer ISE Presents Hydrogen Technologies at the HANNOVER MESSE 2018

23.04.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>