The Graz based research facility CBmed has been appointed the first European “BBMRI-ERIC Expert Centre - Trusted Partner” (Biobanking and BioMolecular resources Research Infrastructure – European Research Infrastructure Consortium). The aim is to reach quicker result in the biomarker analysis and to improve treatments. With the identification of biomarkers it will be possible to individually treat cancer, metabolic diseases, and inflammations of the single patient.
The past few years have shown that not every patient reacts the same way to a treatment. Therefore, medical research is aiming to develop a personalised and tailored treatment of the single patient. To reach this goal the analysis of biomarkers is a very important field. A biomarker is a biologically measurable indicator, such as enzymes, hormones, or genes, measured in biological samples.
Such samples are being evaluated with the consent of the patient and stored in biobanks, like there is the Biobank Graz in Austria. A biobank can be defined as a collection of substances, such as body fluids or tissue samples, and their associated data stored in a database.
The collection includes a large volume of biological material such as DNA samples, blood samples, and tissue samples together with their background information of the donor or organism (clinical history, living condition, identification, place of collection). At the Medical University of Graz biological samples have been collected for research purposes under strict quality control for 30 years.
“We now know that targeted therapies do not have the same result with all of the patients. In case certain mutations can be proven as biomarkers therapies will not have the desired results”, explains Mag.a Dr.in rer.nat Selma Mautner, who is responsible for research management at CBmed.
“The donated samples form a valuable basis for an understanding of diseases that include various clinical symptoms but also a variety of different pathologies. Therefore, it is very important to show the utmost care when dealing with such material. Furthermore, with the introduction of quality criteria and the standardization of the analyzing process the gained data can be compared internationally.”
Pan-European linked research infrastructure
To be able to efficiently search for biological samples for biomarker research a certain infrastructure is necessary. This infrastructure is being provided by the European consortium BBMRI-ERIC, which was founded in 2013 and is today’s largest scientific health infrastructure in Europe. Currently BBMRI-ERIC has 19 member states, including Austria, which helped considerably with building this infrastructure to develop a methodical platform for the collaboration of European biobanks.
This cooperation allows the partners to access biological resources and biomedical installations in order to support efficient and excellent biomolecular and medical research. The “Center For Biomarker Research In Medicine” in Graz (CBmed GmbH) is linking the scientific expertise of the medical universities of Graz and Vienna to innovative technologies of leading international companies in the fields of pharmacy, diagnostics, and medical technology and therefore helps to improve the diagnosis and treatment of cancer, metabolic diseases, and inflammations in the future.
The award as “BBMRI-ERIC Expert Centre - Trusted Partner” proves also for future partners that the analysis of samples happens under strict quality control at the labs of CBmed. There is another advantage: “The shipping of medical samples is rather difficult, as the material can suffer under the transport conditions such as fluctuation in temperature and would therefore deliver falsified results. But in case it can be assured that there are the exact same quality criteria and benchmarks for evaluation and survey, then it will suffice to analyze samples at just one expert centre and to only distribute the results. This means a massive improvement and acceleration of the process”, describes Mautner.
Understanding and resolving of subtypes of diseases
The term stratification describes the characterisation of a disease, for example breast cancer, into different subtypes, each of which needs a different treatment. The more detailed the subtype can be characterised, the more targeted a therapy can be developed.
There are hundreds of biobanks worldwide that provide their data to partners in research and medicine to identify these types. The larger the set of samples is, the higher the chances are to precisely identify relevant subgroups of patients and the higher is also the probability to recognise statistic patterns. Due to the collaboration of the European biobanks the amount of data is increasing, which also influences the development of personalised medicine.
At the Medical University of Graz biological samples have been collected for research purposes under strict quality control for 30 years. The pathologist Univ.-Prof. Dr. Kurt Zatloukal, head of the Austrian branch BBMRI.at, played a substantial role for the founding of BBMRI-ERIC. Graz has a leading position in the international field of biobanks, the headquarter of the European infrastructure BBMRI-ERIC is based in Graz, as well.
CBmed is aiming at becoming the leader in the world of biomarker research
CBmed’s vision is to become the world's most recognized center for biomarker research in personalized medicine expertise in the fields of cancer, metabolism and inflammation by 2030. This will be achieved by integrating cutting-edge technologies with international and interdisciplinary. Together with scientific and industry partners, CBmed is developing solutions and products for patient care and cure.
CBmed is receiving funding from the “COMET” programme and ideally links local research competence with international leading companies. The research facility has a budget of 17.4 mio. EUR for the first funding period from 2015 until 2018. Already in its first year since the founding 34 international science and industry partners have joined the consortium. At the moment CBmed is running six core labs, four of which are located in Graz and the remaining two in Vienna. The goal is to connect excellent research infrastructure and scientific competence with national and international companies for a systematic research of biomarkers in medicine.
Center for Biomarker Research in Medicine
+43 316 385 28801
MSc Melanie Ballach | idw - Informationsdienst Wissenschaft
First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife
Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
25.10.2016 | Earth Sciences
25.10.2016 | Power and Electrical Engineering
25.10.2016 | Process Engineering