Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

53 genes responsible for kidney functionality discovered

21.01.2016

By analysing genetic data from 175,000 people around the world, geneticists at the European Academy of Bolzano (EURAC), heading up the international consortium CKDGen, have now discovered and distinguished 53 genes related to kidney functionality and development. These findings represent an important step in creating an ‘ID card’ for the organ responsible for purifying our blood, while opening up new perspectives for the treatment of kidney failure.

Chronic kidney disease is a serious global health problem. In Italy alone some 3.5 million people suffer from the condition, which in severe cases can lead to dependency on dialysis or even death (10% of the population is likely to be affected throughout their lives). This disease depends upon a number of factors, ranging from diet to lifestyle as well as genetic predisposition.


Cristian Pattaro, researcher of the EURAC Center of Biomedicine

EURAC

A recently-published study in Nature Communications, co-ordinated by Cristian Pattaro, researcher at the European Academy of Bolzano (EURAC) and Caroline Fox from the Harvard Medical School of Boston, USA, now helps shed light on our knowledge of the kidney.

The researchers have discovered and distinguished 53 genes associated with its functionality (its ability to filter metabolic wastes from the blood) and with the development of the organ itself. To achieve this, the geneticists who authored the study examined a huge quantity of data from 175,000 people around the world.

The data were provided by CKDGen (CKD = chronic kidney disease), an international consortium founded in 2009 that consists of some 60 studies in 15 countries worldwide, with EURAC as one of its co-ordinating centres.

“Thanks to the work of the team and the very large amount of data, we were able to conduct extensive bioinformatic analyses. Step by step we are creating a genetic ID card for the kidney,” explains Pattaro “It is a complicated puzzle, but slowly the overall picture is becoming clearer.”

The work will now continue by studying the role of every single gene in detail. For example, it was found that one of the 53 genes catalogued is associated with the ability of the kidney to effectively filter wastes from the blood. The gene can take different forms in different individuals, corresponding to a greater or lesser filtering capacity. Could a malfunction in this feature cause problems for our bodies?

“No gene mutation is in itself lethal, but it may slightly help or hinder the correct function of the kidney,” says Pattaro.

The detailed study of the 53 genes discovered adds new pieces to the complex picture of renal disease, while allowing the identification of the genetic mutations that are especially involved and active in the pathology. Such basic research may in future open new horizons for the development of targeted gene therapies for healthy kidneys.

Weitere Informationen:

https://www.youtube.com/watch?v=DUr2cIuSMcA video interview with Cristian Pattaro, researcher of the EURAC Center of Biomedicine.
http://www.nature.com link to Nature Communications.

Stefanie Gius | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Embryonic development: How do limbs develop from cells?
18.05.2018 | Humboldt-Universität zu Berlin

nachricht Reading histone modifications, an oncoprotein is modified in return
18.05.2018 | American Society for Biochemistry and Molecular Biology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>