Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Standard BMI inadequate for tracking obesity during leukemia therapy

29.01.2016

An interdisciplinary research team at The Saban Research Institute of Children's Hospital Los Angeles has found that body mass index (BMI) is an inadequate method for estimating changes in body fat and obesity in children with leukemia. Investigators determined that the discrepancy between BMI and body composition was due to increases in body fat with simultaneous loss of lean muscle mass during treatment. The study will be published online first in the journal Leukemia & Lymphoma.

Acute lymphoblastic leukemia (ALL) is the most common cancer of childhood. In previous work done at CHLA, investigators reported that obese children diagnosed with high-risk ALL had a 50% greater risk of their disease recurring compared with children who were not obese.


Leukemia cells (yellow) are shown dispersed among fat cells (red) and surrounded by supportive cells (blue).

Credit: Children's Hospital Los Angeles

"In my lab we've seen a direct interaction between fat cells and leukemia cells that may help explain this increased risk of disease relapse," said Steven Mittelman, MD, PhD, director of the Diabetes and Obesity program at CHLA and senior author on the study.

"It appears that the fat cells "protect" leukemia cells, making them less susceptible to chemotherapy - and making an accurate measure of body fat essential." Mittelman is also an associate professor of Pediatrics and Physiology and Biophysics at the Keck School of Medicine of USC.

Typically, BMI is used to estimate body fat and determine obesity. Since BMI is calculated from height and weight measurements, it does not differentiate between fat and muscle tissue. So increases in body fat with concurrent loss of lean muscle could result in an unchanged BMI, and an inaccurate estimation of body composition.

To determine if BMI accurately reflects body fat in this population, 50 patients, predominantly Hispanic between the ages of 10 to 21 years with newly diagnosed high-risk B-precursor ALL or T-cell ALL prospectively enrolled in this trial.

Percentage of total body fat and lean muscle mass was measured directly, using the gold standard of dual-energy X-ray absorptiometry (DXA) at time of diagnosis, one month later, and later during chemotherapy treatment. BMI z-score - a measure of how a given child's BMI deviates from a population of children of the same age and sex - was also determined at these time points.

"We found that change in BMI did not reflect changes in body fat or obesity," said Etan Orgel, MD, first author on the study and an attending physician in the Survivorship & Supportive Care Program at the Children's Center for Cancer and Blood Diseases at CHLA. "In some patients, reaching a "healthy" BMI was due solely to loss of muscle even while body fat continued to rise. Based on these results, we believe that evaluation of obesity in patients with leukemia should include direct measures of body composition."

Additional contributors to the study include Nicole M. Mueske, Richard Sposto, Vicente Gilsanz and David Freyer, all of Children's Hospital Los Angeles. Funding was provided in part by the National Center for Advancing Translational Sciences/NIH (UL1TR000130), the Leukemia and Lymphoma Society (LLS-6249-11), Hyundai Hope on Wheels Foundation, and The Saban Research Institute.

About Children's Hospital Los Angeles

Children's Hospital Los Angeles has been named the best children's hospital in California and among the top 10 in the nation for clinical excellence with its selection to the prestigious U.S. News & World Report Honor Roll. Children's Hospital is home to The Saban Research Institute, one of the largest and most productive pediatric research facilities in the United States. Children's Hospital is also one of America's premier teaching hospitals through its affiliation since 1932 with the Keck School of Medicine of the University of Southern California. For more information, visit CHLA.org. Follow us on Twitter, Facebook, YouTube and LinkedIn, or visit our blog at http://researchlablog.org/.

Ellin Kavanagh | EurekAlert!

Further reports about: ALL BMI Chemotherapy body composition body fat fat cells leukemia leukemia cells

More articles from Interdisciplinary Research:

nachricht Easier Diagnosis of Esophageal Cancer
06.03.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Sandia uses confined nanoparticles to improve hydrogen storage materials performance
27.02.2017 | DOE/Sandia National Laboratories

All articles from Interdisciplinary Research >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Northern oceans pumped CO2 into the atmosphere

27.03.2017 | Earth Sciences

Fingerprint' technique spots frog populations at risk from pollution

27.03.2017 | Life Sciences

Big data approach to predict protein structure

27.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>