Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Standard BMI inadequate for tracking obesity during leukemia therapy

29.01.2016

An interdisciplinary research team at The Saban Research Institute of Children's Hospital Los Angeles has found that body mass index (BMI) is an inadequate method for estimating changes in body fat and obesity in children with leukemia. Investigators determined that the discrepancy between BMI and body composition was due to increases in body fat with simultaneous loss of lean muscle mass during treatment. The study will be published online first in the journal Leukemia & Lymphoma.

Acute lymphoblastic leukemia (ALL) is the most common cancer of childhood. In previous work done at CHLA, investigators reported that obese children diagnosed with high-risk ALL had a 50% greater risk of their disease recurring compared with children who were not obese.


Leukemia cells (yellow) are shown dispersed among fat cells (red) and surrounded by supportive cells (blue).

Credit: Children's Hospital Los Angeles

"In my lab we've seen a direct interaction between fat cells and leukemia cells that may help explain this increased risk of disease relapse," said Steven Mittelman, MD, PhD, director of the Diabetes and Obesity program at CHLA and senior author on the study.

"It appears that the fat cells "protect" leukemia cells, making them less susceptible to chemotherapy - and making an accurate measure of body fat essential." Mittelman is also an associate professor of Pediatrics and Physiology and Biophysics at the Keck School of Medicine of USC.

Typically, BMI is used to estimate body fat and determine obesity. Since BMI is calculated from height and weight measurements, it does not differentiate between fat and muscle tissue. So increases in body fat with concurrent loss of lean muscle could result in an unchanged BMI, and an inaccurate estimation of body composition.

To determine if BMI accurately reflects body fat in this population, 50 patients, predominantly Hispanic between the ages of 10 to 21 years with newly diagnosed high-risk B-precursor ALL or T-cell ALL prospectively enrolled in this trial.

Percentage of total body fat and lean muscle mass was measured directly, using the gold standard of dual-energy X-ray absorptiometry (DXA) at time of diagnosis, one month later, and later during chemotherapy treatment. BMI z-score - a measure of how a given child's BMI deviates from a population of children of the same age and sex - was also determined at these time points.

"We found that change in BMI did not reflect changes in body fat or obesity," said Etan Orgel, MD, first author on the study and an attending physician in the Survivorship & Supportive Care Program at the Children's Center for Cancer and Blood Diseases at CHLA. "In some patients, reaching a "healthy" BMI was due solely to loss of muscle even while body fat continued to rise. Based on these results, we believe that evaluation of obesity in patients with leukemia should include direct measures of body composition."

Additional contributors to the study include Nicole M. Mueske, Richard Sposto, Vicente Gilsanz and David Freyer, all of Children's Hospital Los Angeles. Funding was provided in part by the National Center for Advancing Translational Sciences/NIH (UL1TR000130), the Leukemia and Lymphoma Society (LLS-6249-11), Hyundai Hope on Wheels Foundation, and The Saban Research Institute.

About Children's Hospital Los Angeles

Children's Hospital Los Angeles has been named the best children's hospital in California and among the top 10 in the nation for clinical excellence with its selection to the prestigious U.S. News & World Report Honor Roll. Children's Hospital is home to The Saban Research Institute, one of the largest and most productive pediatric research facilities in the United States. Children's Hospital is also one of America's premier teaching hospitals through its affiliation since 1932 with the Keck School of Medicine of the University of Southern California. For more information, visit CHLA.org. Follow us on Twitter, Facebook, YouTube and LinkedIn, or visit our blog at http://researchlablog.org/.

Ellin Kavanagh | EurekAlert!

Further reports about: ALL BMI Chemotherapy body composition body fat fat cells leukemia leukemia cells

More articles from Interdisciplinary Research:

nachricht Many muons: Imaging the underground with help from the cosmos
19.12.2016 | DOE/Pacific Northwest National Laboratory

nachricht Lego-like wall produces acoustic holograms
17.10.2016 | Duke University

All articles from Interdisciplinary Research >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>