A multidisciplinary team of researchers at KU Leuven (University of Leuven, Belgium) has developed a dental implant that gradually releases drugs from a built-in reservoir. This helps prevent and fight infections.
Our mouth contains many micro-organisms, including bacterial and fungal pathogens. On traditional dental implants, these pathogens can quickly form a so-called biofilm, which is resistant to antimicrobial drugs like antibiotics. As a result, these implants come with a significant risk of infections that may be difficult to treat.
Implant integrated into the jawbone and with a crown on the tooth.
Credit: © KU Leuven - Kaat De Cremer
Conceptual design of the dental implant. Through a cover screw underneath the crown of the tooth, the implant can easily be filled with antimicrobial drugs, anti-inflammatory agents, or substances that stimulate integration into the jawbone.
Credit: © KU Leuven - Annabel Braem
KU Leuven researchers have now developed a new dental implant that reduces the risk of infections. "Our implant has a built-in reservoir underneath the crown of the tooth," explains lead author Kaat De Cremer. "A cover screw makes it easy to fill this reservoir with antimicrobial drugs.
The implant is made of a porous composite material, so that the drugs gradually diffuse from the reservoir to the outside of the implant, which is in direct contact with the bone cells. As a result, the bacteria can no longer form a biofilm."
In the lab, the implant was subjected to various tests for use with chlorhexidine, a universal mouthwash with a powerful antimicrobial effect.
The study shows that the Streptococcus mutans, a type of mouth bacteria that affect the teeth, can no longer form biofilms on the outside of the implant when the reservoir is filled with the mouthwash.
Biofilms that were grown beforehand on the implant could be eliminated in the same way. This means that the implant is effective in terms of both preventing and curing infections.
This study was led by Dr Karin Thevissen, Dr Kaat De Cremer, and Dr Annabel Braem. It is a collaboration between the KU Leuven Centre for Microbial and Plant Genetics, the KU Leuven Department of Materials Engineering, the KU Leuven Biomaterials Research Unit, and the KU Leuven Centre for Surface Chemistry and Catalysis. The study was funded by the KU Leuven Industrial Research Fund.
Karin Thevissen | EurekAlert!
Start of work for the world's largest electric truck
20.04.2018 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt
Tiny implants for cells are functional in vivo
19.03.2018 | Universität Basel
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy