The amount of information that a genome researcher creates and which makes the basis of his scientific work has grown a million times during the last two decades. Today, the challenge does not consist in creating the data, but in exploring them and deducing meaningful conclusions. We believe that this analytical tool, which we have called "EaSeq" can help researchers in doing so, says Associate Professor Klaus Hansen
ChIP sequencing - an insight into the workflow of human cells
The EaSeq software has been developed for analysis of so called ChIP sequencing. DNA sequencing is used for mapping the sequence of the base pairs, which our DNA consists of, and ChIP sequencing is a derived method in which the sequences are used to determine the presence of different cell components in the genome at a given time.
Roughly speaking, ChIP sequencing can be compared to a microscope, which enables us to observe the presence of different cell components in the entire genome at a given time.
The method is still quite young and holds the potential to be applied within many more scientific fields, which can benefit from understanding how healthy and pathological cells control and uses genes, says Associate Professor Mads Lerdrup
Better analytical tools means a broader range of applications
While ChIP sequencing has made it possible to produce enormous amounts of data very fast, the analysis of these data has - until now - been a tedious process. Most of the analytical software being used requires knowledge of computer programming and researchers have therefore been dependent on specialists in order to decode and analyze their data.
EaSeq offers a far more visual and intuitive alternative, which makes it possible for biomedical researchers to study and test hypotheses using their own data. This means that instead of waiting for weeks for others to carry out an analysis, researchers will be able to perform the analyses themselves in a matter of hours.
Today, DNA sequencing is gaining ground within the clinical area where it is e.g. being used for diagnosis and targeting of treatment within the cancer area. The developers of EaSeq see similar perspectives for ChIP sequencing in the clinical work, and in that context strong analytical tools will be pivotal.
- The DNA sequence itself tells us very little about how cells actual decodes the DNA, and to understand this we need to map out which cell components are present in different parts of the genome at a specific time. It is our hope that we by increasing feasibility can enable researchers to faster uncover such knowledge and apply it clinically, says Associate professor Mads Lerdrup
Mads Lerdrup | EurekAlert!
Optical fiber transmits one terabit per second – Novel modulation approach
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Researchers prototype system for reading closed books
09.09.2016 | Massachusetts Institute of Technology
The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
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With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
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For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.
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At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.
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Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.
K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...
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23.09.2016 | Life Sciences
23.09.2016 | Health and Medicine
23.09.2016 | Life Sciences