The amount of information that a genome researcher creates and which makes the basis of his scientific work has grown a million times during the last two decades. Today, the challenge does not consist in creating the data, but in exploring them and deducing meaningful conclusions. We believe that this analytical tool, which we have called "EaSeq" can help researchers in doing so, says Associate Professor Klaus Hansen
ChIP sequencing - an insight into the workflow of human cells
The EaSeq software has been developed for analysis of so called ChIP sequencing. DNA sequencing is used for mapping the sequence of the base pairs, which our DNA consists of, and ChIP sequencing is a derived method in which the sequences are used to determine the presence of different cell components in the genome at a given time.
Roughly speaking, ChIP sequencing can be compared to a microscope, which enables us to observe the presence of different cell components in the entire genome at a given time.
The method is still quite young and holds the potential to be applied within many more scientific fields, which can benefit from understanding how healthy and pathological cells control and uses genes, says Associate Professor Mads Lerdrup
Better analytical tools means a broader range of applications
While ChIP sequencing has made it possible to produce enormous amounts of data very fast, the analysis of these data has - until now - been a tedious process. Most of the analytical software being used requires knowledge of computer programming and researchers have therefore been dependent on specialists in order to decode and analyze their data.
EaSeq offers a far more visual and intuitive alternative, which makes it possible for biomedical researchers to study and test hypotheses using their own data. This means that instead of waiting for weeks for others to carry out an analysis, researchers will be able to perform the analyses themselves in a matter of hours.
Today, DNA sequencing is gaining ground within the clinical area where it is e.g. being used for diagnosis and targeting of treatment within the cancer area. The developers of EaSeq see similar perspectives for ChIP sequencing in the clinical work, and in that context strong analytical tools will be pivotal.
- The DNA sequence itself tells us very little about how cells actual decodes the DNA, and to understand this we need to map out which cell components are present in different parts of the genome at a specific time. It is our hope that we by increasing feasibility can enable researchers to faster uncover such knowledge and apply it clinically, says Associate professor Mads Lerdrup
Mads Lerdrup | EurekAlert!
Drones learn to navigate autonomously by imitating cars and bicycles
23.01.2018 | Universität Zürich
Cloud technology: Dynamic certificates make cloud service providers more secure
15.01.2018 | Technische Universität München
Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.
Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
23.01.2018 | Life Sciences
23.01.2018 | Earth Sciences
23.01.2018 | Physics and Astronomy