Research completed through a collaboration with University of Missouri engineers, biologists, and chemists could transform how scientists study molecules and cells at sub-microscopic (nanoscale) levels.
Shubra Gangopadhyay, an electrical and computer engineer and her team at MU recently published studies outlining a new, relatively inexpensive imaging platform that enables single molecule imaging. This patented method highlights Gangopadhyay's more than 30 years of nanoscale research that has proven invaluable in biological research and battling diseases.
"Usually, scientists have to use very expensive microscopes to image at the sub-microscopic level," said Gangopadhyay, the C.W. LaPierre Endowed Chair of electrical and computer engineering in the MU College of Engineering.
"The techniques we've established help to produce enhanced imaging results with ordinary microscopes. The relatively low production cost for the platform also means it could be used to detect a wide variety of diseases, particularly in developing countries."
The team's custom platform uses an interaction between light and the surface of the metal grating to generate surface plasmon resonance (SPR), a rapidly developing imaging technique that enables super-resolution imaging down to 65 nanometers--a resolution normally reserved for electron microscopes.
Using HD-DVD and Blu-Ray discs as starting templates, a repeating grating pattern is transferred onto the microscope slides where the specimen will be placed. Since the patterns originate a widely used technology, the manufacturing process remains relatively inexpensive.
"In previous studies, we've used plasmonic gratings to detect cortisol and even tuberculosis," Gangopadhyay said. "Additionally, the relatively low production cost for the platform also means it could be used to further detect a wide variety of diseases, particularly in developing countries. Eventually, we might even be able to use smartphones to detect disease in the field."
Gangopadhyay's work also highlights the collaborations that are possible at the Mizzou. Working with the MU Departments of Bioengineering and Biochemistry, the team is helping to develop the next generation of undergraduate and graduate students. Patents and licenses developed by MU technologies help create and enhance relationships with industry, stimulate economic development, and impact the lives of state, national and international citizens.
"Plasmonic gratings with nano-protrusions made by glancing angle deposition (GLAD) for single-molecule super-resolution imaging" recently was published in Nanoscale, a journal of the Royal Society of Chemistry. The National Science Foundation provided partial funding for the studies. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agency.
Jeff Sossamon | EurekAlert!
New epidemic management system combats monkeypox outbreak in Nigeria
15.12.2017 | Helmholtz-Zentrum für Infektionsforschung
Gecko adhesion technology moves closer to industrial uses
13.12.2017 | Georgia Institute of Technology
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences