Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientist from Kiel University coordinates Million Euros Project in Inflammation Research

19.01.2017

Comprehensive EU Funding Programme Supports Personalised Medicine Approaches
The international consortium of the new European research project SYSCID (“A systems medicine approach to chronic inflammatory disease“) aims to develop a personalised medicine approach for inflammatory bowel disease, rheumatoid arthritis and systemic lupus erythematosus. The project coordinated by Kiel University in Germany (CAU) receives a total funding of 14.4 million Euros for a period of five years. Out of this budget Kiel University receives almost three million Euros.

Academic and industry partners from nine different countries join forces to achieve the ambitious goals of the project which has started at the beginning of 2017.

With a lifetime prevalence of over ten percent in the EU, chronic inflammatory disease (CID) poses a major health care burden to modern society. “Our vision is to develop a prediction framework for disease outcome and choice of treatment strategies. With many new targeted therapies coming to the market, we need the right therapy at the right time,” said Professor Philip Rosenstiel from the Institute of Clinical Molecular Biology at Kiel University and scientific coordinator of the SYSCID consortium.

“Our approach combines several biomarker layers from the epigenome to the microbiome, but also aims to investigate more sophisticated tools, such as single cell analysis.”

The new epigenetic markers could be more significant than inflammation markers in the blood which have been used so far. As these ‘traditional’ markers also increase in patients with a common cold or elevated temperature, they cannot always be allocated clearly.

SYSCID will use dense clinical sampling and molecular phenotyping to analyse longitudinal patient cohorts and obtain a deeper understanding of the immunological network changes associated with response and non-response to current treatment regimes. Unlike current therapeutic interventions which mainly alleviate the symptoms, SYSCID aims to develop a therapeutic strategy that will eventually offer a first causal therapy. The consortium targets new therapy approaches by ‘reprogramming’ disease through epigenome editing.

“Assuming that the development and course of a disease are related to long-term epigenetic alterations, it makes sense to target the very root of the disease,” Rosenstiel said.

SYSCID will build on previous and ongoing research activities by partners and international initiatives such as the International Human Epigenome Consortium (IHEC) with the aim of exploiting already collected and established patient data and enabling their utilisation for the development of new clinical applications. Moreover, the project will create training opportunities and career perspectives for young European scientists with its findings serving as a blueprint for future development of precision medicine in other fields.

Contact
Kiel University, Institute of Clinical Molecular Biology
Prof. Dr Philip Rosenstiel
Tel.: +49(0)431/500 15111
p.rosenstiel@mucosa.de

Dr. Tebke Böschen
Tel.: +49(431) 880-4682
E-Mail: tboeschen@uv.uni-kiel.de

Further Information

Project acronym: SYSCID
Start date: 01 January 2017
Duration: 63 months
Budget: € 14.4 Mio
Coordination: Kiel University, Germany

SYSCID Partners at a glance

Belgium
University of Leuven

Croatia
Genos

Denmark
University of Southern Denmark

Germany
Kiel University
Comma Soft AG
European Research and Project Office GmbH
Saarland University
University of Bonn

Greece
Biomedical Research Foundation of the Academy of Athens

Italy
Humanitas University

Luxemburg
University of Luxemburg

Switzerland
University of Geneva

UK
King´s College London
University of Cambridge

Weitere Informationen:

http://www.uni-kiel.de/pressemeldungen/index.php?pmid=2017-010-horizon-2020-foer...

Dr. Boris Pawlowski | Christian-Albrechts-Universität zu Kiel

More articles from Awards Funding:

nachricht Muscle Growth in the Computer: International Team Wants to Unravel the Formation of Myofibrils
13.06.2018 | Technische Universität Dresden

nachricht Innovation Award of the United Nations Environment Programme for PhD Student from ZMT
22.03.2018 | Leibniz-Zentrum für Marine Tropenforschung (ZMT)

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

Im Focus: Water is not the same as water

Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.

From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

A sprinkle of platinum nanoparticles onto graphene makes brain probes more sensitive

15.06.2018 | Materials Sciences

100 % Organic Farming in Bhutan – a Realistic Target?

15.06.2018 | Ecology, The Environment and Conservation

Perovskite-silicon solar cell research collaboration hits 25.2% efficiency

15.06.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>