Two Berlin research teams led by Marie-Laure Yaspo at the Max Planck Institute for Molecular Genetics and Hans Lehrach at Alacris Theranostics GmbH in Berlin are partners in the TREGeneration consortium. Their goal is to develop new strategies for the treatment of Graft versus Host Disease, a serious complication following bone marrow transplantation. A total of 6 million euros was awarded to the consortium to perform a 5-year research project comprising a set of five parallel clinical trials.
Transplantation of stem cells can save the life of patients suffering from leukemia or other blood diseases. Between 30 and 50% of patients undergoing stem cell transplantation suffer from graft versus host disease, a potentially serious condition that results from donor immune cells "attacking" patient tissues like skin, internal organs and mucosa. The TREGeneration project aims to test a cell-based therapeutic approach, expected to result in fewer side effects than the pharmacological strategies currently available.
The project is centered on five clinical trials conducted in parallel by five groups in different European countries. In each trial, patients will be treated with a particular blood cell population called regulatory T cells purified from blood of the original bone marrow donor. These cells have the capacity to suppress the tissue damage caused by T cells from the transplanted bone marrow. These early clinical trials (phase I/II) aim to identify the safe dose to be administered and also to generate preliminary efficacy data.
The task of the Berlin groups of Marie-Laure Yaspo at the Max Planck Institute for Molecular Genetics and Hans Lehrach from Alacris Theranostics GmbH is to characterize the “deep immune status” of patients and donors with a new technology developed by the two groups themselves.
Using next generation sequencing, the scientists will analyze the T cell receptor repertoires in the donor and patient samples at several times after treatment in order to track the fate of individual T cell clones and populations during the clinical trials. The results are expected to contribute to a better understanding of the immune suppressive effects of the regulatory T cell treatment on the patients.
The TREGeneration consortium is led by João Lacerda’s team at the Instituto de Medicina Molecular in Lisbon, Portugal, and comprises eight partners from five European countries. The clinical trials will be run independently by each center and are led by proejct participants: João Forjaz de Lacerda at the Hospital de Santa Maria in Lisbon; Matthias Edinger at the Universitätsklinik in Regensburg, Germany; Frédéric Baron at the Laboratory of Cell and Gene Therapy, Sart-Tilman in Liège, Belgium; and Mario Arpinati at the Department of Hematology “Seràgnoli”, University Hospital S.Orsola-Malpighi, Bologna, Italy.
The data generated by the different clinical trials will be integrated within the framework of the statistical analysis performed by Marta García-Fiñana’s team from the Department of Biostatistics, Faculty of Health & Life Sciences, University of Liverpool, UK. GABO:mi from Munich, Germany, is the project management partner.
The European Research Program Horizon 2020
The European Union regularly announces research programs in order to develop and strenghten the European Research and Innovation Area by funding cross-border research projects. Horizon 2020 is the biggest EU Research and Innovation program ever with nearly €80 billion of funding available over 7 years (2014 to 2020). By fostering international collaboration in research and innovation, Horizon 2020 addresses the huge social challenges like fighting diseases, securing enery requirements or adapting to climate changes. It will support scientists all over the world to collaborate and find solutions for problems of social and global interest.
Dr. Patricia Marquardt | Max-Planck-Institut für molekulare Genetik
Helmholtz International Fellow Award for Sarah Amalia Teichmann
20.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Scientist from Kiel University coordinates Million Euros Project in Inflammation Research
19.01.2017 | Christian-Albrechts-Universität zu Kiel
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Health and Medicine
23.01.2017 | Physics and Astronomy
23.01.2017 | Process Engineering