Application of High-Temperature Superconductor Was the Key. A Big Step Forward in Accelerating the Development of New Drugs and Materials
The research team of Japan's National Institute for Materials Science (NIMS), RIKEN, Kobe Steel and JEOL RESONANCE successfully developed the NMR system equipped with world’s highest magnetic field, 1,020 MHz, supported by the JST-SENTAN program “Development of Systems and Technology for Advanced Measurement and Analysis”.
This research result was published in Journal of Magnetic Resonance on 15 May 2015 (Kenjiro Hashi, Shinobu Ohki, Shinji Matsumoto, Gen Nishijima, Atsushi Goto, Kenzo Deguchi, Kazuhiko Yamada, Takashi Noguchi, Shuji Sakai, Masato Takahashi, Yoshinori Yanagisawa, Seiya Iguchi, Toshio Yamazaki, Hideaki Maeda, Ryoji Tanaka, Takahiro Nemoto, Hiroto Suematsu, Takashi Miki, Kazuyoshi Saito and Tadashi Shimizu, Title:”Achievement of 1,020 MHz NMR”, DOI:10.1016/j.jmr.2015.04.009).
The research team consisting of researchers at NIMS, RIKEN, Kobe Steel and JEOL RESONANCE (a consolidated subsidiary company of JEOL) successfully developed the NMR (nuclear magnetic resonance) system equipped with world’s highest magnetic field, 1,020 MHz, during engagement in the JST-SENTAN program “Development of Systems and Technology for Advanced Measurement and Analysis”. In addition, taking actual measurements with this new system, the team confirmed its considerably enhanced performance compared to conventional NMR systems in terms of sensitivity and resolution.
NMR systems have been used for various purposes including 3D conformational analysis of biopolymers such as proteins, organic chemistry and materials research. In particular, it is one of the indispensable tools for the development of new drugs. In the development of a new drug, it is vital to understand protein structures in a quick and accurate manner.
In this view, improving the performance of NMR systems is of great importance. Magnetic field strength is a key indicator of the performance of NMR systems, and thus there had been fierce competition to develop NMR systems with magnetic fields greater than 1,000 MHz. For a long time, it was broadly expected that the use of high-temperature superconducting technology would enable producing magnetic fields above 1,000 MHz. However, because high-temperature superconductors had problems such as being fragile and difficult to process, no party had achieved their practical use for a long run.
Through developing several new technologies including the conversion of the high-temperature superconductor developed by NIMS in 1988 into the form of wire material, the research team recently created the NMR system equipped with world’s highest magnetic field at 1,020 MHz.
Before making this accomplishment, the team spent 20 years of planning, designing and construction, as well as overcoming many hardships such as suspension of the project due to the damage to the nearly completed system caused by the Great East Japan Earthquake, encountering a serious worldwide shortage of helium supply, and the sudden passing of the team leader.
It is expected that the super-high magnetic field NMR will greatly contribute to various fields such as structural biology, analytical chemistry and materials engineering. Furthermore, considering that NMR requires a magnetic field with extraordinary precision, the high-temperature superconducting technology that was cultivated during the development of NMR is applicable to various high-tech systems such as MRI (magnetic resonance imaging), nuclear fusion, linear motor trains and superconducting power cables.
A part of this study was published in the Journal of Magnetic Resonance on May 15, 2015, and was presented at the Experimental Nuclear Magnetic Resonance Conference, the largest international conference on NMR, held from April 19 to 24 in the United States, and at the 57th Solid-State NMR and Materials Forum held on May 21, 2015 in Japan.
*World’s Highest Magnetic Field: 1020MHz (24.0T) As of Apr 17, 2015
Mikiko Tanifuji | ResearchSEA
Scientists channel graphene to understand filtration and ion transport into cells
11.12.2017 | National Institute of Standards and Technology (NIST)
Successful Mechanical Testing of Nanowires
07.12.2017 | Helmholtz-Zentrum Geesthacht - Zentrum für Material- und Küstenforschung
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
14.12.2017 | Health and Medicine
14.12.2017 | Physics and Astronomy
14.12.2017 | Life Sciences