Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Dynamic DNA polymers can be reversed using biocompatible techniques

18.05.2016

DNA-based straight and branched polymers or nanomaterials that can be created and dissolved using biocompatible methods are now possible thanks to the work of Penn State biomedical engineers.


A nanotree made of DNA can be reversed under standard physiological conditions without burning or other harsh interventions, according to a new study led by Yong Wang, associate professor of biomedical engineering at Penn State.

Credit: Penn State

Synthetic polymers may lead to advances in a broad range of biological and biomedical applications such as drug delivery, molecular detection and bioimaging.

"Achieving reversibility of synthetic polymers and nanomaterials has been a long-standing dream for many biomedical engineers," said Yong Wang, associate professor of biomedical engineering. "Scientists want to see these polymers reverse or disappear when we are finished with them, but that often involves the use of high temperatures and chemical solvents. With that idea in mind, the aim of our study was to create synthetic polymers that would decompose without the use of harsh elements or increased stress. In principle, the polymers could be further tuned to synthesize a diverse array of nanomaterials or bulk materials."

To assemble the dynamic polymers, researchers linked DNA initiators -- straight DNA strands with a single binding domain -- to two DNA monomers with multiple domains. The bonded molecules formed a linear double-stranded DNA structure with a separate and functional side group. The researchers then created a trigger molecule that attached to the side group and initiated a "reverse without the involvement of any non-physiological factors," according to a recent article in Angewandte Chemie International Edition.

The researchers also showed that branched polymers responded to the same technique.

Branched polymers synthesized with a straight polymer and two DNA monomers yielded two functional side groups with the ability to reverse when induced by two molecular triggers.

The researchers performed preliminary testing of the model in water, with subsequent testing conducted on synthetic antibodies. Antibody trials proved that growth and depolymerization of straight and branched polymers were also possible on the microparticle surface and in the extracellular matrix.

Wang and his team are hopeful that by uniting the polymers with various molecules and materials, their findings will hold value for a number of wide-ranging applications.

###

Collaborating with Wang on the project were Niancao Chen, research fellow at Boston Children's Hospital, Harvard Medical School and recent Penn State Ph.D and Xuechen Shi, Penn State graduate student in bioengineering.

Integrated National Science Foundation Support Promoting Interdisciplinary Research and Education and the National Institutes of Health Heart, Lung, and Blood Institute supported this work.

Media Contact

A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481

 @penn_state

http://live.psu.edu 

A'ndrea Elyse Messer | EurekAlert!

More articles from Materials Sciences:

nachricht Decoding cement's shape promises greener concrete
08.12.2016 | Rice University

nachricht Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D
08.12.2016 | DOE/Brookhaven National Laboratory

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>