Production of highly nuclear-spin polarised liquids for MRI and NMR

This novel method, in combination with the device based on the invention, makes the production of highly nuclear-spin-polarised liquids as a contrast medium for MRI and NMR possible for the first time. To achieve this, liquids with a high preservation of the nuclear polarisation, characterised by the so-called T1 time, are mixed with such liquids which exhibit a low vapour pressure of less than 10^-3 mbar at room temperature (20°C). Surprisingly, it was found that so-called ionic liquids exhibit the desired low vapour pressure and can also be mixed with liquids with a high T1 time. Through suitable mixtures, T1 durations of more than 15 minutes could be achieved with liquids at room temperature. Thus, for this time period, the sensitivity e.g. of determination of biological molecules could be increased by a factor of 100 up to 1,000,000.

After preparation, the liquid, which is able to be nuclear-spin polarised, is transferred ? under the formation of a free fluid-film ? into a nearly conventional vacuum apparatus and irradiated with highly nuclear-spin polarised atoms/ions. After removal from the vacuum apparatus ? and a possible concentration method – based on ambient conditions, a highly nuclear-spin polarised contrast medium is avail-able for the purposes of the MRI or NMR, e.g. as a solvent for biomolecules or as an injectable contrast medium.

Further Information: PDF

TransMIT Gesellschaft für Technologietransfer mbH
Phone: +49 (0)641/943 64-12

Contact
Dr. Peter Stumpf

Media Contact

info@technologieallianz.de TechnologieAllianz e.V.

All latest news from the category: Technology Offerings

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors