Influenza – Production of a live attenuated influenza virus vaccine
With a novel method it is possible for the first time to produce a live attenuated influenza A virus vaccine. The method is based on the production of specific mutants of influenza viruses which in vivo are in fact immunogenic, but not pathogenic. Their genome largely corresponds with that of the currently active epidemic strain, allowing their utilisation as attenuated recombinant vaccine against the influenza virus. Due to the particular characteristics of the influenza virus mutants, the application of this vaccine will be possible for children, elderly people and even immunodeficient people.
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