New Enzyme Anhydrofructose-Reductase

The invention affects the novel bacterial enzyme 1,5-anhydro-D-fructose-reductase. In a regio- and stereoselective reaction 1,5-anhydro-D-fructose (AF) is quantitatively reduced to 1,5-anhydro-D-ma-nnitol. Generally AF occurs naturally in connection with the enzymatic degradation of storage poly-saccharides like starch or glycogen and the further eucaryotic metabolism results in the sugar polyol 1,5-anhydro-D-glucitol (so-called Third Gly-cogenolytic Pathway). The bacterial, NADPH-dependent enzyme exhibits a limited substrate spectrum and reduces other structure analogous 2-keto-aldoses. Due to the heterologous expression in E. coli the biocatalyst is available in sufficient amounts. The specific analysis of AF and selective synthesis of the manno-configurated reduction products are counted among the most important areas of application of the new AF-reductase.

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