Novel Pharmaceutical Compounds against Malaria Disease

Several isoquinoline alkaloids with interesting, pharmaceutically useful properties have recently been isolated from marine as well as terrestrial organisms. They served as models for 3,3-dimethyl-8-oxo-di-(or: tetra-)hydroisoquinolines, a compound class which is easily accessible by total synthesis and for which pronounced activities against protozoae have been found in cell vitality assays.

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