Tumor therapy in dogs with interleukin-releasing cell lines*

For the treatment of the majority of tumors diseases in dogs, only classical procedures by surgical removal of the tumor, radiation and chemotherapy are available, the development of new and patient-friendly therapy concepts is indispensable. A new therapeutic strategy provides for the use of biologically active canine interleukines ? especially interleukin-2 (cIL-2) and/or interleukin-12 (cIL-12). These canine interleukines are released by transfected BHK-Tet-on cells and transform in coculture natural killer cells (NK cells) isolated from the patient into lymphokine-activated killer cells (LAK cells), which are, transferred back into the patient, highly effective in the therapy of tumors.

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