GEF-Inhibitors: New small molecules for the treatment of autoimmune and malignant diseases

Scientists at the University of Bonn have identified new small molecules which can be used for the treatment of diseases characterized by alterations of proteins which are affected by Guanine nucleotide Exchange Factors (GEFs). Proteins targeted by GEFs are involved in integrin signalling, vesicle transport, or MAPK-signalling. These processes play an important role in the modulation of the immune response. Therefore, abnormal activation of the target proteins of GEFs can cause autoimmune and tumor diseases in humans.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 0

Dipl.-Ing. Alfred Schillert

Media Contact TechnologieAllianz e.V.

All latest news from the category: Technology Offerings

Back to home

Comments (0)

Write a comment

Newest articles

Prostate cancer organoids open path to precision oncology

A multi-institutional team of investigators led by bioengineer Ankur Singh has developed research tools that shed new light on a virtually untreatable form of prostate cancer, opening a pathway that may lead…

Experimental compound counters diabetic complications

An experimental compound reduced complications of type 1 and type 2 diabetes in mice – not by lowering blood sugar – but by countering its consequences: cell death, inflammation, and…

Taking new aim at COVID-19

The coronavirus’s tangled strands of RNA could offer new ways to treat people who get infected. To the untrained eye, the loops, kinks and folds in the single strand of…

Partners & Sponsors