Nucleoside derivatives with photolabile protective groups
The present technology provides 3'-photolabile nucleoside derivatives for producing nucleotides. The resulting oligonucleotides built up on the support by light-controlled synthesis are linked to the solid phase via the 5' end and thus can be used for investigating reactions that require free 3'-OH ends, for example certain DNA-enzyme interactions.
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DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
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