Molecular marker for tumordiagnosis and – therapy

Metastasis is the most critical factor responsible for the failure of cancer treatment. Although protein expression profiling, gene array analysis and determination of critical risk factors in tumor tissue have improved the diagnostic classification of tumors, it is still difficult to predict the risk of metastasis by analyzing the resected primary tumor.

A prominent example is the endometrial cancer, which is the seventh most common malignant disorder in females. It affects 142,000 women worldwide, whereas 42,000 die from this cancer. The complete tumor resection survival usually depends on occurence of metastasis. The manifestation of the metastasis can affect different viscera and bones.

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