Durable coating with extracellular matrix for cell culture through bio orthogonal functionalization of a extracellular matrix

During a joint research project scientists at the University of Stuttgart and the University of Konstanz developed an ECM with functional groups (clickECM) which is covalently and thus firmly bonded to surfaces via bioorthogonal ligation reactions. The fixed bonding obtained through the click reaction also ensures that the clickECM coating, e.g. when used for cell culture vessels, withstands extensive washing. The coating is highly stable and can be produced economically without any costly purification or isolation processes. The clickECM only differs from a natural ECM in terms of the introduced functional group.

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