Timing is Everything: Hormone Use May Reduce or Increase Alzheimer’s Disease Risk in Women

“This has been an area of debate because observational studies have shown a reduced risk of Alzheimer’s disease with hormone therapy use, while a randomized controlled trial showed an increased risk.

Our results suggest that there may be a critical window near menopause where hormone therapy may possibly be beneficial,” said study author Peter P. Zandi, PhD, with Johns Hopkins University in Baltimore. “On the other hand, if started later in life, hormone therapy could be associated with an increased risk of developing Alzheimer’s disease.”

For the study, researchers followed 1,768 women ages 65 and older for 11 years. The women provided a history of their hormone therapy use and the date at which menopause began. A total of 1,105 women had used hormone therapy, consisting of estrogen alone or in combination with a progestin. During the study, 176 women developed Alzheimer’s disease dementia, including 87 of the 1,105 women who had taken hormone therapy compared to 89 of the 663 others.

The study found that women who began hormone therapy within five years of menopause had a 30-percent lower risk of Alzheimer’s dementia than those who had not used hormone therapy. The risk was unchanged among other hormone users who had begun treatment more than five years after menopause, but a higher risk of dementia was observed among women who had started a combined therapy of estrogen and progestin when they were at least 65 years old.

“While this well-designed study supports the possibility that short-term hormone use may reduce the risk of Alzheimer’s disease, more research is needed before we can make new clinical recommendations for women and their use of hormone therapy,” said Victor Henderson, MD, MS, with Stanford University in Stanford, Calif., and a Fellow of the American Academy of Neurology, who wrote an accompanying editorial.

The study was supported by the National Institute on Aging.

To learn more about Alzheimer’s disease, visit http://www.aan.com/patients.

The American Academy of Neurology, an association of more than 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.

For more information about the American Academy of Neurology, visit http://www.aan.com

Media Contact

Rachel L. Seroka American Academy of Neurology

Weitere Informationen:

http://www.aan.com

Alle Nachrichten aus der Kategorie: Studies and Analyses

innovations-report maintains a wealth of in-depth studies and analyses from a variety of subject areas including business and finance, medicine and pharmacology, ecology and the environment, energy, communications and media, transportation, work, family and leisure.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Safe high-tech batteries for electric cars and laptops

New joint project at the University of Bayreuth Lithium-ion batteries are currently the most important category of electrical energy storage device. Their operational safety depends crucially on separators that ensure…

New study suggests supermassive black holes could form from dark matter

A new theoretical study has proposed a novel mechanism for the creation of supermassive black holes from dark matter. The international team find that rather than the conventional formation scenarios…

Tool that more efficiently analyzes ocean color data will become part of NASA program

Stevens uses machine learning-driven techniques to develop a long-awaited tool that better reveals the health of Earth’s oceans and the impacts of climate change. Researchers at Stevens Institute of Technology…

Partners & Sponsors