Parenteral controlled drug delivery is of crucial importance for the pharmacotherapy of many diseases (e.g. breast and prostate cancer, local inflammation). By means of controlled release systems it is possible to decrease the frequency of administration (from hours to months), to increase drug efficiency and to decrease side effects. Direct Injectable OleoGels (DIOGs) and In Situ Forming OleoGels (ISFOGs) were developed as new, biodegradable and lipid based formulations for parenteral controlled release applications. Both formulations have many advantages in terms of manufacturability, rheological properties and release control compared to the currently used drug delivery systems.
DNA assembly methods such as such as Gibson and Golden Gate cloning are basic tools for synthetic biology. Both methods allow assembly of constructs from multiple DNA fragments in a one-pot one-step assembly reaction. Standardization of parts is another essential element of modern synthetic biology. A novel method has been developed to assemble constructs from several individual DNA parts – each kept on a solid carrier – directly in a one-pot one-step reaction.
Dendrimers are spherical, highly branched polymers used in the fields of drug delivery and drug targeting, DNA/RNA delivery, imaging, protein labelling, protein crosslinking and protein separation, coagulation inhibition, and surface, cell and tissue recognition. They are also used as macroamphiphiles and catalyst supports. All previously existing dendrimers require special, branched and partially protected or polyreactive building blocks for their synthesis. A disadvantage is the limited range of dendrimers with varying structures that can be produced, and the concentration to few dendron forming functional groups.
The new technology offers the possibility of synthesising dendrimers with almost any combination of branch lengths, degree of branching, internal and terminal groups. This is achieved by means of multiple iterative multicomponent reactions, e.g. with acidic, alkaline, hydrophilic, lipophilic, sugar and other functional groups.
The Technology provides a new and outstanding method for the enhancement of the
quality of dim images. Inspired by the spatial integration of visual information in
nocturnal insects, the algorithm successfully enhances the contrast and brightness of
dim images and removes noise while preserving fine details and object contours. The
patented system is applicable to field programmable gate arrays (FPGA) or image
processors, which offer parallel computing capabilities. A wide variety of capabilities
and markets from automotive sector to the enhancement of diagnostic images can be
addressed.
Researchers from the University of Oldenburg, Germany, developed a laser cantilever anemometer (LCA) which utilizes the laser pointer principle of a scanning-force microscope to capture the velocity and the angle of fluid flows.
As yet there has been no satisfactory and easy method to determine the concentrations of substances dissolved in liquid product flows. Previous methods using sensors were not sufficiently reliable and not designed for flow-through systems. Or they required that the analyte whose concentration was to be determined was already known. The device according to invention makes it easy to determine the analyte in a liquid phase both qualitatively and quantitatively.
The Carl von Ossietzky University in Oldenburg, Germany, developed a method which serves the purpose of identifying and quantifying substances (proteins, amino acids, drug constituents) in solution.
The Carl von Ossietzky University in Oldenburg, Germany, developed a method which markedly improved the quantitative determination of hydrogen. A so-called TPR is conducted by coupling a flame ionization detector (FID) to a methanizer. Adding a certain amount of carbon monoxide (CO) and an excess amount of hydrogen immediately upstream of the FID, CO will react with hydrogen to yield methane. Methane produces a FID signal which is proportional to the amount of hydrogen in the sample.
Researchers at the University of Oldenburg have developed a flap for wind turbine generators which is mounted parallel to the main rotor blade and is considerably smaller in its size and mass than the main blade. The core piece of the invention is the adjustable pitch of the flap. The flap's pitch as well as its distance to the main blade can be swiftly adjusted to actual wind variations by means of a control unit or adaptive mechanics, thus assuring an optimal airflow at the site of the main rotor. The flap adjustment unit is able to consider the position of the main blade, the actual rotor rotation speed, and the actual wind speed. A purely mechanical adaptive pitch adjustment is also in a state of planning.
The newly developed method improves the monitoring and control process for beam welding. In contrast to most
commonly used methods, the new monitoring process is root sided, i. e. it takes place on the back part of the
workpiece. Furthermore, the invention describes a monitoring device optimized for beam welding. Beam welding
using the invention avoids incomplete fusion at the weld interface and increases the stability of the weld joint.
Method for reducing cross-talk / interference: The optimal utilization of the available frequency bands plays an important role in the transmission of messages. In frequency multiplexing, sub-frequency bands are allocated to individual communication channels, which are usually completely independent of each other. In practice, however, there is cross-talk, that is, in a channel, signals from the two adjacent channels are also received. Thus, the received signal is composed of useful signal and interference signal. The aim of the present invention is to compensate for the interfering signal component. This is particularly important when the intensity of the adjacent channel signals and thus the interference signal which they contribute are greater than the actual useful signal (“adjacent channel interference problem”).
Charge flow frequency converters are used when especially small electrical currents must be measured. Usually, the integrator and the comparator are connected in series. The improved method can be used anywhere where very small currents of both polarities with high dynamics are measured.
Energy storage systems of electronic components have short lifetimes especially in winter which can be safety-relevant for longer outdoor activities . The present invention includes a means for energy production during nordic skiing activities. The mechanical energy of the pivoting foot movement is transformed into electric energy that can be used for the continual recharging of the energy reservoir.
Changing from injection molding to expansion injection molding requires a costly change of equipment. Scientists at Ostfalia University of Applies Sciences and Volkswagen AG developed a simple and cost-effective way to convert injection molding into expansion molding by simply exchanging the dosing system of current machines.
At the Karlsruhe Institute of Technology (KIT), a new platform concept for the formulation of highly conductive, printable pastes has been developed. Corresponding pastes are free of polymeric or other non-volatile stabilizers and rheology control agents. Nevertheless, rheological properties like low-shear viscosity and yield stress can be adjusted in a wide range. Thus sedimentation /aggregation is prohibited and long-term stability can be guaranteed even for suspensions of high density particles (e.g. Ag, Ni). Also full control of the application behavior in many different printing/coating operations is furnished.
Currently, there are only very few, costly synthetic routes for the production of ultra long-chain compounds, as they typically rely on tedious multistep reaction sequences.
At the University of Konstanz (in the course of a project funded by the Baden-Württemberg Foundation), an iterative method (any multiplication factor) has been developed that produces terminally functionalized, purely aliphatic compounds through a ‘Chain Doubling’ approach starting from common monounsaturated fatty acids. All starting materials are readily available and the individual steps of the catalytic process do not involve further reagents. Moreover, there is only a small amount of byproducts which makes the method very efficient.
The method described here can be applied for the production of high-melting, purely aliphatic polymers and nanocrystals.
We present a new algorithm for the detection of infinite loop bugs in software. Source code is not needed. The algorithm is based on autocorrelation of a program execution’s branch target address sequence. We describe the implementation of the algorithm in a dynamic binary instrumentation tool; the result is light-weight enough to be applied continuously at runtime. Functionality of the tool is
evaluated with infinite loop bug test cases from the Juliet test suite for program analyzers. Applicability of the algorithm to production software is demonstrated by using the tool to detect previously known infinite loop bugs in cgit, Avahi and PHP.
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